Detailed information of TA system TA229794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1691530..1692198
• Replicon: chromosome
• Accession: NZ_CP089949
• Organism: Streptococcus pneumoniae strain SN75752

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LXA49_RS08630
• Protein ID: WP_001132283.1
• Coordinates: 1692019..1692198 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: LXA49_RS08625
• Protein ID: WP_000961810.1
• Coordinates: 1691530..1691982 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXA49_RS08600 (LXA49_08590)	1687420..1688163	-	744	WP_001188208.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
LXA49_RS08605 (LXA49_08595)	1688165..1689115	-	951	WP_000451131.1	50S ribosomal protein L11 methyltransferase	-
LXA49_RS08610 (LXA49_08600)	1689253..1689681	-	429	WP_000418156.1	NUDIX hydrolase	-
LXA49_RS08615 (LXA49_08605)	1689662..1690750	-	1089	WP_000719724.1	site-2 protease family protein	-
LXA49_RS08620 (LXA49_08610)	1690769..1691239	-	471	WP_000257097.1	DUF3013 family protein	-
LXA49_RS08625 (LXA49_08615)	1691530..1691982	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LXA49_RS08630 (LXA49_08620)	1692019..1692198	-	180	WP_001132283.1	type II toxin-antitoxin system HicA family toxin	Toxin
LXA49_RS08635 (LXA49_08625)	1692335..1692514	-	180	WP_001809903.1	hypothetical protein	-
LXA49_RS08640 (LXA49_08630)	1692679..1692918	-	240	WP_000818079.1	hypothetical protein	-
LXA49_RS08645 (LXA49_08635)	1693188..1694459	+	1272	WP_001113216.1	replication-associated recombination protein A	-
LXA49_RS08655 (LXA49_08645)	1695003..1696322	-	1320	WP_000502554.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6596.78 Da
• Isoelectric Point: 10.8214

>T229794 WP_001132283.1 NZ_CP089949:c1692198-1692019 [Streptococcus pneumoniae]
IPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Nucleotide

• Length: 180 bp

>T229794 NZ_CP124517:3938477-3938854 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT229794 WP_000961810.1 NZ_CP089949:c1691982-1691530 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT229794 NZ_CP124517:3938019-3938387 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Antitoxin

• PDB: 5YRZ
• AlphaFold DB: G0IC64