Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1191853..1192351 Replicon chromosome
Accession NZ_CP089949
Organism Streptococcus pneumoniae strain SN75752

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag LXA49_RS05995 Protein ID WP_001809704.1
Coordinates 1191853..1192107 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag LXA49_RS06000 Protein ID WP_000208080.1
Coordinates 1192109..1192351 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXA49_RS05980 (LXA49_05970) 1187126..1189594 - 2469 WP_001152990.1 DNA gyrase subunit A -
LXA49_RS05985 (LXA49_05975) 1189788..1190774 + 987 WP_000204727.1 L-lactate dehydrogenase -
LXA49_RS05990 (LXA49_05980) 1191111..1191806 - 696 WP_000731137.1 potassium channel family protein -
LXA49_RS05995 (LXA49_05985) 1191853..1192107 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXA49_RS06000 (LXA49_05990) 1192109..1192351 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
LXA49_RS06005 (LXA49_05995) 1192545..1193801 + 1257 WP_000530081.1 ISL3 family transposase -
LXA49_RS06010 (LXA49_06000) 1193865..1194674 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
LXA49_RS06015 (LXA49_06005) 1194676..1196025 - 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK -
LXA49_RS06020 (LXA49_06010) 1196018..1196722 - 705 WP_000722076.1 response regulator YycF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1192545..1193801 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T229792 WP_001809704.1 NZ_CP089949:c1192107-1191853 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T229792 NZ_CP124517:3737092-3737265 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT229792 WP_000208080.1 NZ_CP089949:c1192351-1192109 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT229792 NZ_CP124517:3736768-3737064 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References