Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1004256..1005490 Replicon chromosome
Accession NZ_CP089949
Organism Streptococcus pneumoniae strain SN75752

Toxin (Protein)


Gene name zeta Uniprot ID A0A0T8STN7
Locus tag LXA49_RS05190 Protein ID WP_000405351.1
Coordinates 1004732..1005490 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A0T7YHJ0
Locus tag LXA49_RS05185 Protein ID WP_000579620.1
Coordinates 1004256..1004732 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXA49_RS05165 (LXA49_05150) 999329..1000183 + 855 WP_000901913.1 ADP-ribosylglycohydrolase family protein -
LXA49_RS05170 (LXA49_05155) 1000295..1001179 + 885 WP_000757475.1 diacylglycerol kinase family lipid kinase -
LXA49_RS05175 (LXA49_05160) 1001342..1003081 + 1740 Protein_1032 glycoside hydrolase family 13 protein -
LXA49_RS05180 (LXA49_05165) 1003356..1003811 + 456 WP_000500478.1 hypothetical protein -
LXA49_RS05185 (LXA49_05170) 1004256..1004732 + 477 WP_000579620.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
LXA49_RS05190 (LXA49_05175) 1004732..1005490 + 759 WP_000405351.1 type II toxin-antitoxin system toxin PezT Toxin
LXA49_RS05195 (LXA49_05180) 1005888..1006784 - 897 WP_000384879.1 tyrosine-type recombinase/integrase -
LXA49_RS05200 (LXA49_05185) 1007114..1008883 + 1770 WP_000002882.1 DUF4365 domain-containing protein -
LXA49_RS05205 (LXA49_05190) 1008912..1009196 + 285 WP_000403447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 995467..1044752 49285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28752.57 Da        Isoelectric Point: 6.5919

>T229791 WP_000405351.1 NZ_CP089949:1004732-1005490 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAATVLHDLLFGELNQVEKEML
KSGEERLKDLTN

Download         Length: 759 bp

>T229791 NZ_CP124517:3408882-3409193 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18235.65 Da        Isoelectric Point: 4.3462

>AT229791 WP_000579620.1 NZ_CP089949:1004256-1004732 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT229791 NZ_CP124517:3409194-3409484 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T8STN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0T7YHJ0

References