Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1156976..1157474 | Replicon | chromosome |
Accession | NZ_CP089948 | ||
Organism | Streptococcus pneumoniae TIGR4 |
Toxin (Protein)
Gene name | relE | Uniprot ID | B1IC19 |
Locus tag | LXA46_RS05705 | Protein ID | WP_001809704.1 |
Coordinates | 1156976..1157230 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | B1IC20 |
Locus tag | LXA46_RS05710 | Protein ID | WP_000208080.1 |
Coordinates | 1157232..1157474 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LXA46_RS05700 (LXA46_05690) | 1155030..1156901 | - | 1872 | WP_000150986.1 | Eco57I restriction-modification methylase domain-containing protein | - |
LXA46_RS05705 (LXA46_05695) | 1156976..1157230 | - | 255 | WP_001809704.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LXA46_RS05710 (LXA46_05700) | 1157232..1157474 | - | 243 | WP_000208080.1 | DUF6290 family protein | Antitoxin |
LXA46_RS05715 (LXA46_05705) | 1157565..1158374 | - | 810 | WP_001289493.1 | MBL fold metallo-hydrolase | - |
LXA46_RS05720 (LXA46_05710) | 1158376..1159725 | - | 1350 | WP_000886219.1 | cell wall metabolism sensor histidine kinase VicK | - |
LXA46_RS05725 (LXA46_05715) | 1159718..1160422 | - | 705 | WP_000722076.1 | response regulator YycF | - |
LXA46_RS05730 (LXA46_05720) | 1160478..1161653 | - | 1176 | WP_000886146.1 | A/G-specific adenine glycosylase | - |
LXA46_RS10935 | 1161750..1161875 | + | 126 | WP_001818232.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10098.79 Da Isoelectric Point: 10.7632
>T229788 WP_001809704.1 NZ_CP089948:c1157230-1156976 [Streptococcus pneumoniae TIGR4]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY
Download Length: 255 bp
>T229788 NZ_CP124517:c2908436-2907909 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9205.46 Da Isoelectric Point: 4.0527
>AT229788 WP_000208080.1 NZ_CP089948:c1157474-1157232 [Streptococcus pneumoniae TIGR4]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE
Download Length: 243 bp
>AT229788 NZ_CP124517:c2908709-2908443 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A853PEW4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A064C2J7 |