Detailed information of TA system TA229780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3290276..3290882
• Replicon: chromosome
• Accession: NZ_CP089942
• Organism: Erwinia tracheiphila strain MDCuke

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LU604_RS17640
• Protein ID: WP_233478912.1
• Coordinates: 3290276..3290455 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LU604_RS17645
• Protein ID: WP_233478913.1
• Coordinates: 3290478..3290882 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3287061..3288101	1040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6649.79 Da
• Isoelectric Point: 10.9132

>T229780 WP_233478912.1 NZ_CP089942:3290276-3290455 [Erwinia tracheiphila]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHSQKDIPQPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T229780 NZ_CP089942:3290276-3290455 [Erwinia tracheiphila]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTAAGAGTAAAAGGCAGTCATCACCAGTT
CAAGCACCCAACGAAAAAAGGGCTGGTAACGGTAAAACATTCACAGAAGGACATACCGCAACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14615.53 Da
• Isoelectric Point: 4.1880

>AT229780 WP_233478913.1 NZ_CP089942:3290478-3290882 [Erwinia tracheiphila]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLVEDGEGLPEATSVENWLADPDYVDVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGRI

Nucleotide

• Length: 405 bp

>AT229780 NZ_CP089942:3290478-3290882 [Erwinia tracheiphila]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTGCCTGATATTCCAGGCTGCTTCTCTGG
CGGAGACAACTATCAGGATGCGATTGAGAGCGTCCGCGAGGCTATTGACGCACATATCGAATTACTTGTGGAAGATGGCG
AAGGGTTGCCGGAGGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTAGACGTGGTATGGGCGCTGGTTGAT
GTGGACGTTACCCGATTAATGGGGAAAGCGGAAAAGATAAACGTCACGCTCCCTTCGCTGCTTATCCGCCGTATCGACCA
ATTTGTGGCCGCGCATCCTGAATACGGTAGCCGTTCCGGTTTCCTATCCCGTGTCGCTGCAGATAAAGTCATTGGCAGGA
TCTGA