Detailed information of TA system TA229770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1413893..1414412
• Replicon: chromosome
• Accession: NZ_CP089942
• Organism: Erwinia tracheiphila strain MDCuke

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LU604_RS07505
• Protein ID: WP_233480300.1
• Coordinates: 1414128..1414412 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1X0W393
• Locus tag: LU604_RS07500
• Protein ID: WP_008815935.1
• Coordinates: 1413893..1414135 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU604_RS07470 (LU604_07470)	1409145..1409239	-	95	Protein_1477	IS6 family transposase	-
LU604_RS07475 (LU604_07475)	1409871..1410239	+	369	WP_233480299.1	hypothetical protein	-
LU604_RS07480 (LU604_07480)	1410399..1410626	-	228	Protein_1479	DDE-type integrase/transposase/recombinase	-
LU604_RS07485 (LU604_07485)	1410888..1411424	+	537	WP_233481546.1	transposase zinc-binding domain-containing protein	-
LU604_RS07490 (LU604_07490)	1411406..1412410	+	1005	Protein_1481	IS91 family transposase	-
LU604_RS07495 (LU604_07495)	1412554..1412880	+	327	Protein_1482	incFII family plasmid replication initiator RepA	-
LU604_RS07500 (LU604_07500)	1413893..1414135	+	243	WP_008815935.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LU604_RS07505 (LU604_07505)	1414128..1414412	+	285	WP_233480300.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LU604_RS26935	1414572..1415141	-	570	WP_267938748.1	transposase	-
LU604_RS26940	1415131..1415796	-	666	Protein_1486	transposase zinc-binding domain-containing protein	-
LU604_RS07515 (LU604_07515)	1415878..1416129	-	252	Protein_1487	recombinase family protein	-
LU604_RS07520 (LU604_07520)	1416179..1416667	+	489	WP_233480753.1	phage tail protein	-
LU604_RS07525 (LU604_07525)	1416667..1417263	+	597	WP_016191668.1	tail fiber assembly protein	-
LU604_RS07530 (LU604_07530)	1417238..1417846	-	609	WP_016191669.1	tail assembly chaperone	-
LU604_RS07535 (LU604_07535)	1417846..1418760	-	915	WP_233480302.1	tail fiber protein	-
LU604_RS07540 (LU604_07540)	1418763..1419341	-	579	WP_233480303.1	phage tail protein I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1306323..1452575	146252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-88)

Antitoxin

• Antitoxin ParD (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11067.59 Da
• Isoelectric Point: 6.3252

>T229770 WP_233480300.1 NZ_CP089942:1414128-1414412 [Erwinia tracheiphila]
VYKLTERAAEDFAGIYDYTLLKFGEAQADHYTDALEAFFETLSGMPDMGRDYNAVPGVMRIEFQRHIIFYTVRDTDILIA
RILHQQMNHKRHLR

Nucleotide

• Length: 285 bp

>T229770 NZ_CP124515:3631233-3631451 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8860.98 Da
• Isoelectric Point: 7.0130

>AT229770 WP_008815935.1 NZ_CP089942:1413893-1414135 [Erwinia tracheiphila]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVVRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Nucleotide

• Length: 243 bp

>AT229770 NZ_CP124515:3630833-3631207 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1X0W393