Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 159156..159826 | Replicon | chromosome |
| Accession | NC_011060 | ||
| Organism | Pelodictyon phaeoclathratiforme BU-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PPHA_RS00795 | Protein ID | WP_012506994.1 |
| Coordinates | 159156..159569 (-) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | B4SB76 |
| Locus tag | PPHA_RS00800 | Protein ID | WP_012506995.1 |
| Coordinates | 159566..159826 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PPHA_RS00765 | 154542..154832 | - | 291 | WP_041526368.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| PPHA_RS00770 | 154820..155089 | - | 270 | WP_012506989.1 | hypothetical protein | - |
| PPHA_RS00775 | 155255..155719 | + | 465 | WP_012506990.1 | Rrf2 family transcriptional regulator | - |
| PPHA_RS00780 | 155732..156625 | + | 894 | WP_012506991.1 | 4Fe-4S binding protein | - |
| PPHA_RS00785 | 156694..157110 | + | 417 | WP_041526597.1 | tetratricopeptide repeat protein | - |
| PPHA_RS00790 | 157132..158760 | + | 1629 | WP_012506993.1 | hydroxylamine reductase | - |
| PPHA_RS14805 | 158915..159064 | - | 150 | Protein_134 | phenylalanine--tRNA ligase subunit alpha | - |
| PPHA_RS00795 | 159156..159569 | - | 414 | WP_012506994.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| PPHA_RS00800 | 159566..159826 | - | 261 | WP_012506995.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| PPHA_RS00805 | 159988..160439 | + | 452 | Protein_137 | site-specific DNA-methyltransferase | - |
| PPHA_RS00810 | 160531..160878 | + | 348 | WP_150085745.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| PPHA_RS00815 | 160878..161159 | + | 282 | WP_150085747.1 | XRE family transcriptional regulator | - |
| PPHA_RS00820 | 161452..161769 | + | 318 | WP_041526598.1 | nucleotidyltransferase family protein | - |
| PPHA_RS15795 | 161762..161902 | + | 141 | WP_012507000.1 | hypothetical protein | - |
| PPHA_RS00830 | 161971..162198 | + | 228 | WP_012507001.1 | addiction module protein | - |
| PPHA_RS14810 | 162250..162413 | - | 164 | Protein_143 | phenylalanine--tRNA ligase subunit alpha | - |
| PPHA_RS00835 | 162641..162901 | + | 261 | WP_012507002.1 | UPF0175 family protein | - |
| PPHA_RS00840 | 162885..163367 | + | 483 | WP_012507003.1 | DUF3368 domain-containing protein | - |
| PPHA_RS14815 | 163472..163959 | + | 488 | Protein_146 | site-specific DNA-methyltransferase | - |
| PPHA_RS00850 | 164076..164399 | - | 324 | WP_012507004.1 | DNA-binding transcriptional regulator | - |
| PPHA_RS00855 | 164392..164766 | - | 375 | WP_012507005.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 150085..164399 | 14314 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15251.96 Da Isoelectric Point: 8.9064
>T22977 WP_012506994.1 NC_011060:c159569-159156 [Pelodictyon phaeoclathratiforme BU-1]
MSLYMLDTNIASHVIKGDIPLVRERLIAVPIQRVVISSVTQAELLYGLAKRTYPKGLTARVHEFLIRVKILAWDKEVAIV
YGDLRAKCETTGVTLSPLDLMIAAHAQAVNAILVTGDKAFTRIQDRLIIENWTLSPD
MSLYMLDTNIASHVIKGDIPLVRERLIAVPIQRVVISSVTQAELLYGLAKRTYPKGLTARVHEFLIRVKILAWDKEVAIV
YGDLRAKCETTGVTLSPLDLMIAAHAQAVNAILVTGDKAFTRIQDRLIIENWTLSPD
Download Length: 414 bp
>T22977 NC_011060:c159569-159156 [Pelodictyon phaeoclathratiforme BU-1]
ATGAGCCTCTACATGCTTGATACAAATATTGCCAGTCATGTTATCAAAGGAGACATTCCTCTTGTGCGAGAGCGGCTGAT
TGCTGTACCAATACAGCGCGTTGTGATATCTTCAGTTACACAGGCAGAATTACTCTATGGCCTGGCAAAACGAACCTATC
CGAAGGGCCTTACCGCCCGCGTCCATGAGTTTTTGATCCGGGTAAAAATATTGGCCTGGGATAAAGAGGTTGCCATCGTT
TATGGTGATCTTCGAGCCAAGTGCGAAACCACAGGTGTGACGCTCTCACCACTTGACCTCATGATTGCGGCTCATGCTCA
GGCAGTCAATGCCATTCTTGTTACGGGAGATAAAGCGTTTACCAGAATCCAAGATCGATTAATTATAGAAAATTGGACAC
TGTCACCAGACTGA
ATGAGCCTCTACATGCTTGATACAAATATTGCCAGTCATGTTATCAAAGGAGACATTCCTCTTGTGCGAGAGCGGCTGAT
TGCTGTACCAATACAGCGCGTTGTGATATCTTCAGTTACACAGGCAGAATTACTCTATGGCCTGGCAAAACGAACCTATC
CGAAGGGCCTTACCGCCCGCGTCCATGAGTTTTTGATCCGGGTAAAAATATTGGCCTGGGATAAAGAGGTTGCCATCGTT
TATGGTGATCTTCGAGCCAAGTGCGAAACCACAGGTGTGACGCTCTCACCACTTGACCTCATGATTGCGGCTCATGCTCA
GGCAGTCAATGCCATTCTTGTTACGGGAGATAAAGCGTTTACCAGAATCCAAGATCGATTAATTATAGAAAATTGGACAC
TGTCACCAGACTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9853.05 Da Isoelectric Point: 4.4964
>AT22977 WP_012506995.1 NC_011060:c159826-159566 [Pelodictyon phaeoclathratiforme BU-1]
MPVTAKIFMSGRSQAVRLPKEFRFEGKEVFIRRDAISGDVILSHHPDSWAGLFELDTTTEVPADFMQADDRTQPEQLRDP
FEGWAE
MPVTAKIFMSGRSQAVRLPKEFRFEGKEVFIRRDAISGDVILSHHPDSWAGLFELDTTTEVPADFMQADDRTQPEQLRDP
FEGWAE
Download Length: 261 bp
>AT22977 NC_011060:c159826-159566 [Pelodictyon phaeoclathratiforme BU-1]
ATGCCTGTTACTGCAAAAATTTTTATGTCAGGGCGCAGTCAAGCCGTCCGATTACCGAAGGAGTTCCGTTTTGAGGGGAA
AGAGGTGTTTATCCGTCGTGATGCAATTTCCGGAGATGTCATTTTGTCACACCATCCCGATTCATGGGCAGGGCTGTTTG
AGCTTGATACAACAACTGAGGTGCCTGCCGATTTTATGCAGGCTGACGATCGAACGCAACCAGAGCAATTGCGAGATCCT
TTTGAGGGTTGGGCAGAATGA
ATGCCTGTTACTGCAAAAATTTTTATGTCAGGGCGCAGTCAAGCCGTCCGATTACCGAAGGAGTTCCGTTTTGAGGGGAA
AGAGGTGTTTATCCGTCGTGATGCAATTTCCGGAGATGTCATTTTGTCACACCATCCCGATTCATGGGCAGGGCTGTTTG
AGCTTGATACAACAACTGAGGTGCCTGCCGATTTTATGCAGGCTGACGATCGAACGCAACCAGAGCAATTGCGAGATCCT
TTTGAGGGTTGGGCAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|