Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 159156..159826 Replicon chromosome
Accession NC_011060
Organism Pelodictyon phaeoclathratiforme BU-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PPHA_RS00795 Protein ID WP_012506994.1
Coordinates 159156..159569 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4SB76
Locus tag PPHA_RS00800 Protein ID WP_012506995.1
Coordinates 159566..159826 (-) Length 87 a.a.

Genomic Context

PPHA_RS00775PPHA_RS00780PPHA_RS00785PPHA_RS00790PPHA_RS00805PPHA_RS00810PPHA_RS00815PPHA_RS00820PPHA_RS15795PPHA_RS00830PPHA_RS00835PPHA_RS00840PPHA_RS14815PPHA_RS00765PPHA_RS00770PPHA_RS14805PPHA_RS00795PPHA_RS00800PPHA_RS14810PPHA_RS00850PPHA_RS00855
Location: 155255..155719 (465 bp)
Type: Others
Protein ID: WP_012506990.1
Location: 155732..156625 (894 bp)
Type: Others
Protein ID: WP_012506991.1
Location: 156694..157110 (417 bp)
Type: Others
Protein ID: WP_041526597.1
Location: 157132..158760 (1629 bp)
Type: Others
Protein ID: WP_012506993.1
Location: 159988..160439 (452 bp)
Type: Others
Protein ID: Protein_137
Location: 160531..160878 (348 bp)
Type: Others
Protein ID: WP_150085745.1
Location: 160878..161159 (282 bp)
Type: Others
Protein ID: WP_150085747.1
Location: 161452..161769 (318 bp)
Type: Others
Protein ID: WP_041526598.1
Location: 161762..161902 (141 bp)
Type: Others
Protein ID: WP_012507000.1
Location: 161971..162198 (228 bp)
Type: Others
Protein ID: WP_012507001.1
Location: 162641..162901 (261 bp)
Type: Others
Protein ID: WP_012507002.1
Location: 162885..163367 (483 bp)
Type: Others
Protein ID: WP_012507003.1
Location: 163472..163959 (488 bp)
Type: Others
Protein ID: Protein_146
Location: 154542..154832 (291 bp)
Type: Others
Protein ID: WP_041526368.1
Location: 154820..155089 (270 bp)
Type: Others
Protein ID: WP_012506989.1
Location: 158915..159064 (150 bp)
Type: Others
Protein ID: Protein_134
Location: 159156..159569 (414 bp)
Type: Toxin
Protein ID: WP_012506994.1
Location: 159566..159826 (261 bp)
Type: Antitoxin
Protein ID: WP_012506995.1
Location: 162250..162413 (164 bp)
Type: Others
Protein ID: Protein_143
Location: 164076..164399 (324 bp)
Type: Others
Protein ID: WP_012507004.1
Location: 164392..164766 (375 bp)
Type: Others
Protein ID: WP_012507005.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PPHA_RS00765154542..154832-291WP_041526368.1type II toxin-antitoxin system RelE/ParE family toxin-
PPHA_RS00770154820..155089-270WP_012506989.1hypothetical protein-
PPHA_RS00775155255..155719+465WP_012506990.1Rrf2 family transcriptional regulator-
PPHA_RS00780155732..156625+894WP_012506991.14Fe-4S binding protein-
PPHA_RS00785156694..157110+417WP_041526597.1tetratricopeptide repeat protein-
PPHA_RS00790157132..158760+1629WP_012506993.1hydroxylamine reductase-
PPHA_RS14805158915..159064-150Protein_134phenylalanine--tRNA ligase subunit alpha-
PPHA_RS00795159156..159569-414WP_012506994.1type II toxin-antitoxin system VapC family toxinToxin
PPHA_RS00800159566..159826-261WP_012506995.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
PPHA_RS00805159988..160439+452Protein_137site-specific DNA-methyltransferase-
PPHA_RS00810160531..160878+348WP_150085745.1type II toxin-antitoxin system RelE/ParE family toxin-
PPHA_RS00815160878..161159+282WP_150085747.1XRE family transcriptional regulator-
PPHA_RS00820161452..161769+318WP_041526598.1nucleotidyltransferase family protein-
PPHA_RS15795161762..161902+141WP_012507000.1hypothetical protein-
PPHA_RS00830161971..162198+228WP_012507001.1addiction module protein-
PPHA_RS14810162250..162413-164Protein_143phenylalanine--tRNA ligase subunit alpha-
PPHA_RS00835162641..162901+261WP_012507002.1UPF0175 family protein-
PPHA_RS00840162885..163367+483WP_012507003.1DUF3368 domain-containing protein-
PPHA_RS14815163472..163959+488Protein_146site-specific DNA-methyltransferase-
PPHA_RS00850164076..164399-324WP_012507004.1DNA-binding transcriptional regulator-
PPHA_RS00855164392..164766-375WP_012507005.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--150085..16439914314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-41)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15251.96 Da        Isoelectric Point: 8.9064

>T22977 WP_012506994.1 NC_011060:c159569-159156 [Pelodictyon phaeoclathratiforme BU-1]
MSLYMLDTNIASHVIKGDIPLVRERLIAVPIQRVVISSVTQAELLYGLAKRTYPKGLTARVHEFLIRVKILAWDKEVAIV
YGDLRAKCETTGVTLSPLDLMIAAHAQAVNAILVTGDKAFTRIQDRLIIENWTLSPD

Download         Length: 414 bp

>T22977 NC_011060:c159569-159156 [Pelodictyon phaeoclathratiforme BU-1]
ATGAGCCTCTACATGCTTGATACAAATATTGCCAGTCATGTTATCAAAGGAGACATTCCTCTTGTGCGAGAGCGGCTGAT
TGCTGTACCAATACAGCGCGTTGTGATATCTTCAGTTACACAGGCAGAATTACTCTATGGCCTGGCAAAACGAACCTATC
CGAAGGGCCTTACCGCCCGCGTCCATGAGTTTTTGATCCGGGTAAAAATATTGGCCTGGGATAAAGAGGTTGCCATCGTT
TATGGTGATCTTCGAGCCAAGTGCGAAACCACAGGTGTGACGCTCTCACCACTTGACCTCATGATTGCGGCTCATGCTCA
GGCAGTCAATGCCATTCTTGTTACGGGAGATAAAGCGTTTACCAGAATCCAAGATCGATTAATTATAGAAAATTGGACAC
TGTCACCAGACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9853.05 Da        Isoelectric Point: 4.4964

>AT22977 WP_012506995.1 NC_011060:c159826-159566 [Pelodictyon phaeoclathratiforme BU-1]
MPVTAKIFMSGRSQAVRLPKEFRFEGKEVFIRRDAISGDVILSHHPDSWAGLFELDTTTEVPADFMQADDRTQPEQLRDP
FEGWAE

Download         Length: 261 bp

>AT22977 NC_011060:c159826-159566 [Pelodictyon phaeoclathratiforme BU-1]
ATGCCTGTTACTGCAAAAATTTTTATGTCAGGGCGCAGTCAAGCCGTCCGATTACCGAAGGAGTTCCGTTTTGAGGGGAA
AGAGGTGTTTATCCGTCGTGATGCAATTTCCGGAGATGTCATTTTGTCACACCATCCCGATTCATGGGCAGGGCTGTTTG
AGCTTGATACAACAACTGAGGTGCCTGCCGATTTTATGCAGGCTGACGATCGAACGCAACCAGAGCAATTGCGAGATCCT
TTTGAGGGTTGGGCAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB4SB76

References