Detailed information of TA system TA229768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 888155..888689
• Replicon: chromosome
• Accession: NZ_CP089942
• Organism: Erwinia tracheiphila strain MDCuke

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6P1V8P2
• Locus tag: LU604_RS04570
• Protein ID: WP_000143805.1
• Coordinates: 888399..888689 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7I6XZR7
• Locus tag: LU604_RS04565
• Protein ID: WP_000104338.1
• Coordinates: 888155..888409 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU604_RS04530 (LU604_04530)	883539..883892	-	354	WP_233481509.1	hypothetical protein	-
LU604_RS04535 (LU604_04535)	883849..884121	-	273	WP_233480011.1	hypothetical protein	-
LU604_RS04540 (LU604_04540)	884360..884563	+	204	WP_233480897.1	hypothetical protein	-
LU604_RS04545 (LU604_04545)	884971..885423	-	453	WP_233480012.1	H-NS family nucleoid-associated regulatory protein	-
LU604_RS26890	885571..886116	-	546	WP_252120243.1	transposase	-
LU604_RS26895	886113..886793	-	681	WP_252120230.1	transposase zinc-binding domain-containing protein	-
LU604_RS04555 (LU604_04555)	886875..887378	-	504	Protein_897	DUF4158 domain-containing protein	-
LU604_RS04560 (LU604_04560)	887488..887778	+	291	WP_233480013.1	hypothetical protein	-
LU604_RS04565 (LU604_04565)	888155..888409	+	255	WP_000104338.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LU604_RS04570 (LU604_04570)	888399..888689	+	291	WP_000143805.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LU604_RS04575 (LU604_04575)	889033..890256	-	1224	WP_233481510.1	IS91 family transposase	-
LU604_RS04580 (LU604_04580)	890355..890774	+	420	WP_233480739.1	recombinase family protein	-
LU604_RS04585 (LU604_04585)	891013..891930	+	918	WP_233480014.1	hypothetical protein	-
LU604_RS04590 (LU604_04590)	892051..892650	+	600	WP_233481511.1	DUF2913 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hsiB1/vipA / hsiC1/vipB	746383..1192486	446103
	-	flank	IS/Tn	-	-	886857..887357	500

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-47)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11463.41 Da
• Isoelectric Point: 10.2689

>T229768 WP_000143805.1 NZ_CP089942:888399-888689 [Erwinia tracheiphila]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Nucleotide

• Length: 291 bp

>T229768 NZ_CP124515:2963012-2963290 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9708.04 Da
• Isoelectric Point: 4.4247

>AT229768 WP_000104338.1 NZ_CP089942:888155-888409 [Erwinia tracheiphila]
MSTIQIRVDDELKKDAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Nucleotide

• Length: 255 bp

>AT229768 NZ_CP124515:2962819-2963010 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Structures

Toxin

• AlphaFold DB: A0A6P1V8P2

Antitoxin

• AlphaFold DB: A0A7I6XZR7