Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 314099..314700 Replicon chromosome
Accession NZ_CP089942
Organism Erwinia tracheiphila strain MDCuke

Toxin (Protein)


Gene name doc Uniprot ID A0A0M2K9A2
Locus tag LU604_RS01590 Protein ID WP_046371846.1
Coordinates 314317..314700 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID H3R939
Locus tag LU604_RS01585 Protein ID WP_006117881.1
Coordinates 314099..314320 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU604_RS01555 (LU604_01555) 309131..309514 + 384 WP_016193222.1 hypothetical protein -
LU604_RS01560 (LU604_01560) 309514..312009 + 2496 WP_052734706.1 replication endonuclease -
LU604_RS01565 (LU604_01565) 311975..312400 + 426 WP_233479718.1 hypothetical protein -
LU604_RS01570 (LU604_01570) 312456..312731 + 276 WP_233479719.1 type II toxin-antitoxin system HicA family toxin -
LU604_RS01575 (LU604_01575) 312728..313087 + 360 WP_046371849.1 type II toxin-antitoxin system HicB family antitoxin -
LU604_RS01580 (LU604_01580) 313337..314032 + 696 WP_233479720.1 DNA adenine methylase -
LU604_RS01585 (LU604_01585) 314099..314320 + 222 WP_006117881.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LU604_RS01590 (LU604_01590) 314317..314700 + 384 WP_046371846.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LU604_RS01595 (LU604_01595) 315186..315689 + 504 WP_233479721.1 hypothetical protein -
LU604_RS01600 (LU604_01600) 315760..316818 - 1059 WP_016193218.1 phage portal protein -
LU604_RS01605 (LU604_01605) 316818..318548 - 1731 WP_233481461.1 terminase family protein -
LU604_RS01610 (LU604_01610) 318708..319544 + 837 WP_016193215.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 301714..353654 51940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14129.14 Da        Isoelectric Point: 4.9094

>T229767 WP_046371846.1 NZ_CP089942:314317-314700 [Erwinia tracheiphila]
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH

Download         Length: 384 bp

>T229767 NZ_CP124515:2799477-2799584 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8110.06 Da        Isoelectric Point: 5.0644

>AT229767 WP_006117881.1 NZ_CP089942:314099-314320 [Erwinia tracheiphila]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR

Download         Length: 222 bp

>AT229767 NZ_CP124515:c2799420-2799365 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2K9A2

Antitoxin

Source ID Structure
AlphaFold DB A0A068Z6U5

References