Detailed information of TA system TA229766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 312456..313087
• Replicon: chromosome
• Accession: NZ_CP089942
• Organism: Erwinia tracheiphila strain MDCuke

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LU604_RS01570
• Protein ID: WP_233479719.1
• Coordinates: 312456..312731 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0M2K504
• Locus tag: LU604_RS01575
• Protein ID: WP_046371849.1
• Coordinates: 312728..313087 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU604_RS01540 (LU604_01540)	308278..308484	+	207	WP_016193242.1	hypothetical protein	-
LU604_RS01545 (LU604_01545)	308502..308768	+	267	Protein_299	hypothetical protein	-
LU604_RS01550 (LU604_01550)	308816..309058	+	243	WP_016193223.1	hypothetical protein	-
LU604_RS01555 (LU604_01555)	309131..309514	+	384	WP_016193222.1	hypothetical protein	-
LU604_RS01560 (LU604_01560)	309514..312009	+	2496	WP_052734706.1	replication endonuclease	-
LU604_RS01565 (LU604_01565)	311975..312400	+	426	WP_233479718.1	hypothetical protein	-
LU604_RS01570 (LU604_01570)	312456..312731	+	276	WP_233479719.1	type II toxin-antitoxin system HicA family toxin	Toxin
LU604_RS01575 (LU604_01575)	312728..313087	+	360	WP_046371849.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LU604_RS01580 (LU604_01580)	313337..314032	+	696	WP_233479720.1	DNA adenine methylase	-
LU604_RS01585 (LU604_01585)	314099..314320	+	222	WP_006117881.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LU604_RS01590 (LU604_01590)	314317..314700	+	384	WP_046371846.1	type II toxin-antitoxin system death-on-curing family toxin	-
LU604_RS01595 (LU604_01595)	315186..315689	+	504	WP_233479721.1	hypothetical protein	-
LU604_RS01600 (LU604_01600)	315760..316818	-	1059	WP_016193218.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	301714..353654	51940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10068.60 Da
• Isoelectric Point: 11.1780

>T229766 WP_233479719.1 NZ_CP089942:312456-312731 [Erwinia tracheiphila]
MNQAVKNLRKKQRDTLEQIFRTSPPSGLKWSAVESLIGALCGKIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGAVVSL
REWLESTGVKP

Nucleotide

• Length: 276 bp

>T229766 NZ_CP124515:2547398-2548720 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13355.08 Da
• Isoelectric Point: 4.5809

>AT229766 WP_046371849.1 NZ_CP089942:312728-313087 [Erwinia tracheiphila]
MTKPATPNMIVIAGQPAVVSYVPEINMFRGRFLGLTGYCDFVSDSIQGLNKEGDISLREYLEDCSAEGIEPYARQEKTRT
FTLRYPESFGERLNQAAAENEVSVNAFIVETLNERMKHA

Nucleotide

• Length: 360 bp

>AT229766 NZ_CP124515:2547132-2547398 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M2K504