Detailed information of TA system TA229765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 287962..288424
• Replicon: chromosome
• Accession: NZ_CP089942
• Organism: Erwinia tracheiphila strain MDCuke

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LU604_RS01395
• Protein ID: WP_233479705.1
• Coordinates: 287962..288237 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0M2KKT1
• Locus tag: LU604_RS01400
• Protein ID: WP_016192654.1
• Coordinates: 288224..288424 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU604_RS01360 (LU604_01360)	283074..283223	+	150	Protein_262	transposase	-
LU604_RS01365 (LU604_01365)	283357..284463	-	1107	WP_233479702.1	beta-propeller fold lactonase family protein	-
LU604_RS01370 (LU604_01370)	284460..284645	-	186	WP_233481459.1	hypothetical protein	-
LU604_RS01375 (LU604_01375)	284635..284811	-	177	WP_161796999.1	hypothetical protein	-
LU604_RS01380 (LU604_01380)	285071..285667	-	597	WP_016193254.1	YhgN family NAAT transporter	-
LU604_RS01385 (LU604_01385)	285935..287044	+	1110	WP_233479703.1	aspartate-semialdehyde dehydrogenase	-
LU604_RS01390 (LU604_01390)	287137..287834	+	698	WP_233479704.1	IS1 family transposase	-
LU604_RS01395 (LU604_01395)	287962..288237	-	276	WP_233479705.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LU604_RS01400 (LU604_01400)	288224..288424	-	201	WP_016192654.1	hypothetical protein	Antitoxin
LU604_RS01405 (LU604_01405)	288721..289074	+	354	WP_016192655.1	RAQPRD family integrative conjugative element protein	-
LU604_RS01410 (LU604_01410)	289075..289203	+	129	WP_233479706.1	DUF3262 family protein	-
LU604_RS01415 (LU604_01415)	289240..289617	+	378	Protein_273	TIGR03745 family integrating conjugative element membrane protein	-
LU604_RS01420 (LU604_01420)	289629..289718	+	90	Protein_274	DUF3487 family protein	-
LU604_RS01425 (LU604_01425)	289804..290670	+	867	WP_233479707.1	TIGR03749 family integrating conjugative element protein	-
LU604_RS01430 (LU604_01430)	290679..292193	+	1515	WP_233480720.1	TIGR03752 family integrating conjugative element protein	-
LU604_RS01435 (LU604_01435)	292205..292465	+	261	WP_152664198.1	hypothetical protein	-
LU604_RS01440 (LU604_01440)	292452..292856	+	405	WP_233479708.1	TIGR03751 family conjugal transfer lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	287331..287834	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10729.21 Da
• Isoelectric Point: 6.2090

>T229765 WP_233479705.1 NZ_CP089942:c288237-287962 [Erwinia tracheiphila]
VQWVKWKESALNDLADIIDYIEQYNPVASRKLHQQIVHVAENLPQHPYLYRPGRVAGTREIVVHPNYLVVYHIDDFEIEI
LGVLHARQEYP

Nucleotide

• Length: 276 bp

>T229765 NZ_CP124515:2266715-2266817 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7605.66 Da
• Isoelectric Point: 5.8151

>AT229765 WP_016192654.1 NZ_CP089942:c288424-288224 [Erwinia tracheiphila]
MTTKLSPIVSEFETQEQADSYDRWFRAKVQVALDDPRPGIPHDDAMAKLEAMLEERRTLRAKRAMG

Nucleotide

• Length: 201 bp

>AT229765 NZ_CP124515:c2266855-2266587 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A0M2KKT1