Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3950581..3951182 Replicon chromosome
Accession NZ_CP089940
Organism Erwinia tracheiphila strain BuffGH

Toxin (Protein)


Gene name doc Uniprot ID A0A0M2K9A2
Locus tag LU631_RS20710 Protein ID WP_046371846.1
Coordinates 3950581..3950964 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID H3R939
Locus tag LU631_RS20715 Protein ID WP_006117881.1
Coordinates 3950961..3951182 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU631_RS20685 (LU631_20685) 3945633..3945773 + 141 WP_161796965.1 hypothetical protein -
LU631_RS20690 (LU631_20690) 3945782..3946996 + 1215 WP_046371879.1 IS91 family transposase -
LU631_RS20695 (LU631_20695) 3947148..3948539 + 1392 Protein_4093 terminase family protein -
LU631_RS20700 (LU631_20700) 3948539..3949597 + 1059 WP_046371980.1 phage portal protein -
LU631_RS20705 (LU631_20705) 3949668..3950171 - 504 WP_016193219.1 hypothetical protein -
LU631_RS20710 (LU631_20710) 3950581..3950964 - 384 WP_046371846.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LU631_RS20715 (LU631_20715) 3950961..3951182 - 222 WP_006117881.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LU631_RS20720 (LU631_20720) 3951249..3951944 - 696 WP_046371847.1 DNA methylase -
LU631_RS20725 (LU631_20725) 3952194..3952553 - 360 WP_046371849.1 type II toxin-antitoxin system HicB family antitoxin -
LU631_RS20730 (LU631_20730) 3952573..3952839 - 267 WP_046371850.1 hypothetical protein -
LU631_RS20735 (LU631_20735) 3952805..3955300 - 2496 WP_052734703.1 replication endonuclease -
LU631_RS20740 (LU631_20740) 3955300..3955683 - 384 WP_046371981.1 hypothetical protein -
LU631_RS20745 (LU631_20745) 3955756..3955998 - 243 WP_016193223.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3929205..4005344 76139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14129.14 Da        Isoelectric Point: 4.9094

>T229762 WP_046371846.1 NZ_CP089940:c3950964-3950581 [Erwinia tracheiphila]
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH

Download         Length: 384 bp

>T229762 NZ_CP124515:2010355-2010606 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8110.06 Da        Isoelectric Point: 5.0644

>AT229762 WP_006117881.1 NZ_CP089940:c3951182-3950961 [Erwinia tracheiphila]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR

Download         Length: 222 bp

>AT229762 NZ_CP124515:2010603-2010857 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2K9A2

Antitoxin

Source ID Structure
AlphaFold DB A0A068Z6U5

References