Detailed information of TA system TA022976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 21238..21814
• Replicon: chromosome
• Accession: NC_011060
• Organism: Pelodictyon phaeoclathratiforme BU-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PPHA_RS00100
• Protein ID: WP_041526349.1
• Coordinates: 21542..21814 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PPHA_RS00095
• Protein ID: WP_012506877.1
• Coordinates: 21238..21555 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PPHA_RS00075	17373..19322	-	1950	WP_012506873.1	DNA topoisomerase (ATP-hydrolyzing) subunit B	-
PPHA_RS00080	19407..19793	-	387	WP_012506874.1	YraN family protein	-
PPHA_RS00085	19790..20410	-	621	WP_012506875.1	ribonuclease HII	-
PPHA_RS00090	20484..21158	-	675	WP_012506876.1	DUF2461 domain-containing protein	-
PPHA_RS00095	21238..21555	-	318	WP_012506877.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PPHA_RS00100	21542..21814	-	273	WP_041526349.1	type II toxin-antitoxin system HicA family toxin	Toxin
PPHA_RS00110	22598..24286	+	1689	WP_012506880.1	Rne/Rng family ribonuclease	-
PPHA_RS00115	24313..25176	+	864	WP_012506881.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-84)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10403.98 Da
• Isoelectric Point: 8.5452

>T22976 WP_041526349.1 NC_011060:c21814-21542 [Pelodictyon phaeoclathratiforme BU-1]
MFVHKKQQKILTRIFEDPVRSDVKWCDIETLIQGLGAEISEGNGSRVRIFLNGVRAVFHRPHPEKECDKSALKSIRRFLQ
EAGVEYHAEL

Nucleotide

• Length: 273 bp

>T22976 NC_011060:c21814-21542 [Pelodictyon phaeoclathratiforme BU-1]
TTGTTCGTGCATAAAAAACAGCAAAAAATTTTAACCAGGATCTTTGAAGATCCGGTACGCTCTGACGTGAAGTGGTGCGA
TATTGAAACGCTGATACAGGGTCTGGGAGCAGAAATTTCCGAGGGAAACGGATCAAGAGTACGGATTTTTTTGAATGGGG
TTCGTGCAGTTTTTCACAGGCCGCATCCCGAAAAGGAGTGTGACAAAAGTGCGCTTAAATCAATAAGACGTTTTTTACAA
GAAGCAGGAGTGGAGTACCATGCTGAACTATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11913.39 Da
• Isoelectric Point: 5.5442

>AT22976 WP_012506877.1 NC_011060:c21555-21238 [Pelodictyon phaeoclathratiforme BU-1]
MLNYKGYTGHIEFDDEAGLFHGEVVDTKDVVTFQGRSVDEIVQAFRDSVDDYLEFCAERGEKPDKPFSGKFVLRMNPELH
HAIHLKAIKAGKSLNKWVNDTLQSA

Nucleotide

• Length: 318 bp

>AT22976 NC_011060:c21555-21238 [Pelodictyon phaeoclathratiforme BU-1]
ATGCTGAACTATAAGGGATACACAGGGCATATTGAGTTTGACGATGAGGCCGGTCTGTTTCATGGCGAGGTAGTCGACAC
GAAAGATGTCGTCACCTTTCAGGGACGCAGTGTTGATGAGATCGTGCAGGCGTTCCGGGATTCTGTCGATGATTATCTCG
AATTTTGTGCAGAGCGGGGCGAAAAACCGGATAAGCCATTTTCCGGTAAATTTGTACTGAGAATGAACCCGGAACTGCAC
CATGCCATTCATCTGAAGGCAATAAAAGCAGGAAAAAGCCTAAACAAATGGGTCAATGATACACTCCAGTCAGCCTGA