Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 2541965..2542566 | Replicon | chromosome |
| Accession | NZ_CP089940 | ||
| Organism | Erwinia tracheiphila strain BuffGH | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A0M2K9A2 |
| Locus tag | LU631_RS13570 | Protein ID | WP_046371846.1 |
| Coordinates | 2541965..2542348 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | H3R939 |
| Locus tag | LU631_RS13575 | Protein ID | WP_006117881.1 |
| Coordinates | 2542345..2542566 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LU631_RS13550 (LU631_13550) | 2537196..2538032 | - | 837 | WP_016193215.1 | GPO family capsid scaffolding protein | - |
| LU631_RS13555 (LU631_13555) | 2538192..2539922 | + | 1731 | WP_040465939.1 | terminase family protein | - |
| LU631_RS13560 (LU631_13560) | 2539922..2540981 | + | 1060 | Protein_2668 | phage portal protein | - |
| LU631_RS13565 (LU631_13565) | 2541052..2541555 | - | 504 | WP_016193219.1 | hypothetical protein | - |
| LU631_RS13570 (LU631_13570) | 2541965..2542348 | - | 384 | WP_046371846.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LU631_RS13575 (LU631_13575) | 2542345..2542566 | - | 222 | WP_006117881.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LU631_RS13580 (LU631_13580) | 2542633..2543328 | - | 696 | WP_046371847.1 | DNA methylase | - |
| LU631_RS13585 (LU631_13585) | 2543578..2543937 | - | 360 | WP_046371849.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LU631_RS13590 (LU631_13590) | 2543957..2544223 | - | 267 | WP_046371850.1 | hypothetical protein | - |
| LU631_RS13595 (LU631_13595) | 2544189..2546708 | - | 2520 | WP_052734690.1 | replication endonuclease | - |
| LU631_RS13600 (LU631_13600) | 2546708..2547091 | - | 384 | WP_016193222.1 | hypothetical protein | - |
| LU631_RS13605 (LU631_13605) | 2547164..2547406 | - | 243 | WP_016193223.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2520558..2553587 | 33029 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14129.14 Da Isoelectric Point: 4.9094
>T229759 WP_046371846.1 NZ_CP089940:c2542348-2541965 [Erwinia tracheiphila]
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH
Download Length: 384 bp
>T229759 NZ_CP124515:645572-645886 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8110.06 Da Isoelectric Point: 5.0644
>AT229759 WP_006117881.1 NZ_CP089940:c2542566-2542345 [Erwinia tracheiphila]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR
Download Length: 222 bp
>AT229759 NZ_CP124515:645883-646299 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2K9A2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068Z6U5 |