Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 2172015..2172592 | Replicon | chromosome |
| Accession | NZ_CP089940 | ||
| Organism | Erwinia tracheiphila strain BuffGH | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A0M2KF28 |
| Locus tag | LU631_RS11570 | Protein ID | WP_016192194.1 |
| Coordinates | 2172281..2172592 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0M2K853 |
| Locus tag | LU631_RS11565 | Protein ID | WP_016192195.1 |
| Coordinates | 2172015..2172293 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LU631_RS11530 (LU631_11530) | 2167924..2168376 | - | 453 | Protein_2264 | IS6 family transposase | - |
| LU631_RS11535 (LU631_11535) | 2168371..2169114 | - | 744 | Protein_2265 | transposase | - |
| LU631_RS11540 (LU631_11540) | 2169208..2169681 | - | 474 | WP_016192197.1 | DUF3757 domain-containing protein | - |
| LU631_RS11545 (LU631_11545) | 2169836..2170060 | - | 225 | WP_051124401.1 | hypothetical protein | - |
| LU631_RS11550 (LU631_11550) | 2170117..2170269 | - | 153 | WP_161796973.1 | hypothetical protein | - |
| LU631_RS11555 (LU631_11555) | 2170410..2170583 | + | 174 | Protein_2269 | hypothetical protein | - |
| LU631_RS11560 (LU631_11560) | 2170647..2171753 | + | 1107 | WP_233482028.1 | IS91 family transposase | - |
| LU631_RS11565 (LU631_11565) | 2172015..2172293 | + | 279 | WP_016192195.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| LU631_RS11570 (LU631_11570) | 2172281..2172592 | + | 312 | WP_016192194.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LU631_RS11575 (LU631_11575) | 2172718..2173152 | + | 435 | Protein_2273 | DDE-type integrase/transposase/recombinase | - |
| LU631_RS11580 (LU631_11580) | 2173317..2174534 | - | 1218 | WP_040465737.1 | IS91 family transposase | - |
| LU631_RS11585 (LU631_11585) | 2174521..2174751 | - | 231 | WP_046371992.1 | hypothetical protein | - |
| LU631_RS11590 (LU631_11590) | 2174870..2175106 | + | 237 | Protein_2276 | transposase | - |
| LU631_RS11595 (LU631_11595) | 2175180..2175877 | + | 698 | WP_152664192.1 | IS1 family transposase | - |
| LU631_RS11600 (LU631_11600) | 2175981..2176427 | - | 447 | WP_071598937.1 | FAD-dependent oxidoreductase | - |
| LU631_RS11605 (LU631_11605) | 2176424..2177137 | - | 714 | WP_016192189.1 | FAD-dependent oxidoreductase | - |
| LU631_RS11610 (LU631_11610) | 2177130..2177441 | - | 312 | WP_016192188.1 | cupin domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2169836..2194295 | 24459 | |
| - | inside | IScluster/Tn | - | - | 2170410..2175877 | 5467 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11746.62 Da Isoelectric Point: 9.4808
>T229750 WP_016192194.1 NZ_CP089940:2172281-2172592 [Erwinia tracheiphila]
MPQVIVSALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTQPDMGRPVSLLPLEYQELVIGFGDSGYVMLYRHDR
ETDQIVILTALHQKEAGYRGLQE
MPQVIVSALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTQPDMGRPVSLLPLEYQELVIGFGDSGYVMLYRHDR
ETDQIVILTALHQKEAGYRGLQE
Download Length: 312 bp
>T229750 NZ_CP124513:c4147727-4147440 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10727.70 Da Isoelectric Point: 4.6216
>AT229750 WP_016192195.1 NZ_CP089940:2172015-2172293 [Erwinia tracheiphila]
MSAATSIRLDDELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLSAEEVESWIDTWG
TENEQDAPSCHR
MSAATSIRLDDELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLSAEEVESWIDTWG
TENEQDAPSCHR
Download Length: 279 bp
>AT229750 NZ_CP124513:c4147453-4147151 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2KF28 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2K853 |