Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2172015..2172592 Replicon chromosome
Accession NZ_CP089940
Organism Erwinia tracheiphila strain BuffGH

Toxin (Protein)


Gene name parE Uniprot ID A0A0M2KF28
Locus tag LU631_RS11570 Protein ID WP_016192194.1
Coordinates 2172281..2172592 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M2K853
Locus tag LU631_RS11565 Protein ID WP_016192195.1
Coordinates 2172015..2172293 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU631_RS11530 (LU631_11530) 2167924..2168376 - 453 Protein_2264 IS6 family transposase -
LU631_RS11535 (LU631_11535) 2168371..2169114 - 744 Protein_2265 transposase -
LU631_RS11540 (LU631_11540) 2169208..2169681 - 474 WP_016192197.1 DUF3757 domain-containing protein -
LU631_RS11545 (LU631_11545) 2169836..2170060 - 225 WP_051124401.1 hypothetical protein -
LU631_RS11550 (LU631_11550) 2170117..2170269 - 153 WP_161796973.1 hypothetical protein -
LU631_RS11555 (LU631_11555) 2170410..2170583 + 174 Protein_2269 hypothetical protein -
LU631_RS11560 (LU631_11560) 2170647..2171753 + 1107 WP_233482028.1 IS91 family transposase -
LU631_RS11565 (LU631_11565) 2172015..2172293 + 279 WP_016192195.1 CopG family ribbon-helix-helix protein Antitoxin
LU631_RS11570 (LU631_11570) 2172281..2172592 + 312 WP_016192194.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LU631_RS11575 (LU631_11575) 2172718..2173152 + 435 Protein_2273 DDE-type integrase/transposase/recombinase -
LU631_RS11580 (LU631_11580) 2173317..2174534 - 1218 WP_040465737.1 IS91 family transposase -
LU631_RS11585 (LU631_11585) 2174521..2174751 - 231 WP_046371992.1 hypothetical protein -
LU631_RS11590 (LU631_11590) 2174870..2175106 + 237 Protein_2276 transposase -
LU631_RS11595 (LU631_11595) 2175180..2175877 + 698 WP_152664192.1 IS1 family transposase -
LU631_RS11600 (LU631_11600) 2175981..2176427 - 447 WP_071598937.1 FAD-dependent oxidoreductase -
LU631_RS11605 (LU631_11605) 2176424..2177137 - 714 WP_016192189.1 FAD-dependent oxidoreductase -
LU631_RS11610 (LU631_11610) 2177130..2177441 - 312 WP_016192188.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2169836..2194295 24459
- inside IScluster/Tn - - 2170410..2175877 5467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11746.62 Da        Isoelectric Point: 9.4808

>T229750 WP_016192194.1 NZ_CP089940:2172281-2172592 [Erwinia tracheiphila]
MPQVIVSALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTQPDMGRPVSLLPLEYQELVIGFGDSGYVMLYRHDR
ETDQIVILTALHQKEAGYRGLQE

Download         Length: 312 bp

>T229750 NZ_CP124513:c4147727-4147440 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10727.70 Da        Isoelectric Point: 4.6216

>AT229750 WP_016192195.1 NZ_CP089940:2172015-2172293 [Erwinia tracheiphila]
MSAATSIRLDDELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLSAEEVESWIDTWG
TENEQDAPSCHR

Download         Length: 279 bp

>AT229750 NZ_CP124513:c4147453-4147151 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2KF28

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2K853

References