Detailed information of TA system TA022975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2276125..2276593
• Replicon: chromosome
• Accession: NC_011059
• Organism: Prosthecochloris aestuarii DSM 271

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: PAES_RS10435
• Protein ID: WP_012506635.1
• Coordinates: 2276125..2276385 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A5C4S0N8
• Locus tag: PAES_RS10440
• Protein ID: WP_041702602.1
• Coordinates: 2276369..2276593 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAES_RS10410	2271723..2272613	-	891	WP_012506630.1	DUF58 domain-containing protein	-
PAES_RS10415	2272747..2273745	-	999	WP_012506631.1	AAA family ATPase	-
PAES_RS10420	2273758..2273982	-	225	WP_012506632.1	hypothetical protein	-
PAES_RS10425	2274016..2275053	+	1038	WP_012506633.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
PAES_RS10430	2275273..2275677	+	405	Protein_2043	catalase-peroxidase	-
PAES_RS10435	2276125..2276385	-	261	WP_012506635.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PAES_RS10440	2276369..2276593	-	225	WP_041702602.1	ribbon-helix-helix protein, CopG family	Antitoxin
PAES_RS10445	2277034..2278599	+	1566	WP_150084410.1	Fic family protein	-
PAES_RS10450	2278627..2279112	+	486	Protein_2047	helix-turn-helix domain-containing protein	-
PAES_RS10455	2279109..2280125	+	1017	WP_208597042.1	IS3 family transposase	-
PAES_RS10460	2280458..2281162	-	705	WP_012506640.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Relaxosome protein TraY (8-48)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9993.63 Da
• Isoelectric Point: 10.6828

>T22975 WP_012506635.1 NC_011059:c2276385-2276125 [Prosthecochloris aestuarii DSM 271]
MVWTIEFAATAEKELSKLDKSAAKRILKFLKERVATDPRSSGKALRGDHAGLWRYRIGDYRVICEFRDQTVSVLVVRIGH
RKEVYR

Nucleotide

• Length: 261 bp

>T22975 NC_011059:c2276385-2276125 [Prosthecochloris aestuarii DSM 271]
TTGGTCTGGACGATTGAGTTTGCCGCGACGGCGGAAAAGGAATTGTCCAAGTTGGATAAATCTGCGGCAAAGCGGATTCT
CAAATTTCTGAAAGAGCGTGTTGCCACTGATCCCCGCTCATCGGGCAAAGCGTTGCGTGGCGATCATGCCGGACTCTGGC
GGTATCGCATCGGTGATTATCGGGTGATTTGCGAATTTCGGGATCAGACCGTTTCGGTTCTTGTCGTTCGGATCGGGCAT
CGGAAAGAGGTTTATCGGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8594.77 Da
• Isoelectric Point: 4.8605

>AT22975 WP_041702602.1 NC_011059:c2276593-2276369 [Prosthecochloris aestuarii DSM 271]
MIGIRIPKSVGQRLDNLAKRTGRTKTWYVREAIMAHLDDLEDIYLAEQVLERVRRGEEAVSDIDEVERRLGLDD

Nucleotide

• Length: 225 bp

>AT22975 NC_011059:c2276593-2276369 [Prosthecochloris aestuarii DSM 271]
ATGATCGGAATTCGTATTCCGAAGAGCGTGGGTCAACGGCTGGATAACCTTGCCAAAAGAACTGGCCGAACCAAGACCTG
GTATGTTCGCGAGGCGATAATGGCGCATCTCGATGATCTTGAAGACATTTATCTGGCAGAACAGGTTCTCGAACGTGTGA
GGCGTGGAGAAGAGGCTGTGTCCGATATAGATGAAGTGGAGCGTCGTCTTGGTCTGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A5C4S0N8