Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2119815..2120416 Replicon chromosome
Accession NZ_CP089940
Organism Erwinia tracheiphila strain BuffGH

Toxin (Protein)


Gene name doc Uniprot ID A0A0M2K9A2
Locus tag LU631_RS11240 Protein ID WP_046371846.1
Coordinates 2119815..2120198 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID H3R939
Locus tag LU631_RS11245 Protein ID WP_006117881.1
Coordinates 2120195..2120416 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU631_RS11220 (LU631_11220) 2115047..2115883 - 837 WP_016193215.1 GPO family capsid scaffolding protein -
LU631_RS11225 (LU631_11225) 2116043..2117773 + 1731 WP_040465939.1 terminase family protein -
LU631_RS11230 (LU631_11230) 2117773..2118831 + 1059 WP_016193218.1 phage portal protein -
LU631_RS11235 (LU631_11235) 2118902..2119405 - 504 WP_016193219.1 hypothetical protein -
LU631_RS11240 (LU631_11240) 2119815..2120198 - 384 WP_046371846.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LU631_RS11245 (LU631_11245) 2120195..2120416 - 222 WP_006117881.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LU631_RS11250 (LU631_11250) 2120483..2121178 - 696 WP_046371847.1 DNA methylase -
LU631_RS11255 (LU631_11255) 2121428..2121787 - 360 WP_046371849.1 type II toxin-antitoxin system HicB family antitoxin -
LU631_RS11260 (LU631_11260) 2121807..2122073 - 267 WP_046371850.1 hypothetical protein -
LU631_RS11265 (LU631_11265) 2122039..2124558 - 2520 WP_052734690.1 replication endonuclease -
LU631_RS11270 (LU631_11270) 2124558..2124941 - 384 WP_016193222.1 hypothetical protein -
LU631_RS11275 (LU631_11275) 2125014..2125256 - 243 WP_016193223.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleD 2083703..2130951 47248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14129.14 Da        Isoelectric Point: 4.9094

>T229749 WP_046371846.1 NZ_CP089940:c2120198-2119815 [Erwinia tracheiphila]
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH

Download         Length: 384 bp

>T229749 NZ_CP124513:c4037754-4037440 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8110.06 Da        Isoelectric Point: 5.0644

>AT229749 WP_006117881.1 NZ_CP089940:c2120416-2120195 [Erwinia tracheiphila]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR

Download         Length: 222 bp

>AT229749 NZ_CP124513:c4037990-4037757 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2K9A2

Antitoxin

Source ID Structure
AlphaFold DB A0A068Z6U5

References