Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1346824..1347286 | Replicon | chromosome |
| Accession | NZ_CP089940 | ||
| Organism | Erwinia tracheiphila strain BuffGH | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0M2KDZ1 |
| Locus tag | LU631_RS06905 | Protein ID | WP_016192653.1 |
| Coordinates | 1346824..1347099 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0M2KKT1 |
| Locus tag | LU631_RS06910 | Protein ID | WP_016192654.1 |
| Coordinates | 1347086..1347286 (-) | Length | 67 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LU631_RS06875 (LU631_06875) | 1341993..1343213 | - | 1221 | WP_046371806.1 | ISL3 family transposase | - |
| LU631_RS06880 (LU631_06880) | 1343319..1343480 | - | 162 | WP_161796998.1 | hypothetical protein | - |
| LU631_RS06885 (LU631_06885) | 1343494..1343670 | - | 177 | WP_161796999.1 | hypothetical protein | - |
| LU631_RS06890 (LU631_06890) | 1343933..1344529 | - | 597 | WP_016193254.1 | YhgN family NAAT transporter | - |
| LU631_RS06895 (LU631_06895) | 1344797..1345906 | + | 1110 | WP_016193253.1 | aspartate-semialdehyde dehydrogenase | - |
| LU631_RS06900 (LU631_06900) | 1345999..1346696 | + | 698 | WP_233481998.1 | IS1 family transposase | - |
| LU631_RS06905 (LU631_06905) | 1346824..1347099 | - | 276 | WP_016192653.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| LU631_RS06910 (LU631_06910) | 1347086..1347286 | - | 201 | WP_016192654.1 | hypothetical protein | Antitoxin |
| LU631_RS06915 (LU631_06915) | 1347583..1347936 | + | 354 | WP_016192655.1 | RAQPRD family integrative conjugative element protein | - |
| LU631_RS06920 (LU631_06920) | 1347937..1348065 | + | 129 | WP_016192656.1 | DUF3262 family protein | - |
| LU631_RS06925 (LU631_06925) | 1348102..1348479 | + | 378 | WP_016192657.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| LU631_RS06930 (LU631_06930) | 1348491..1348580 | + | 90 | Protein_1364 | DUF3487 family protein | - |
| LU631_RS06935 (LU631_06935) | 1348666..1349544 | + | 879 | WP_016192659.1 | TIGR03749 family integrating conjugative element protein | - |
| LU631_RS06940 (LU631_06940) | 1349541..1351055 | + | 1515 | WP_152664262.1 | TIGR03752 family integrating conjugative element protein | - |
| LU631_RS06945 (LU631_06945) | 1351067..1351327 | + | 261 | WP_016193251.1 | hypothetical protein | - |
| LU631_RS06950 (LU631_06950) | 1351314..1351718 | + | 405 | WP_016193250.1 | TIGR03751 family conjugal transfer lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | acrB / acrA | 1346249..1667188 | 320939 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10828.34 Da Isoelectric Point: 6.4863
>T229747 WP_016192653.1 NZ_CP089940:c1347099-1346824 [Erwinia tracheiphila]
VQWVKWKESALNDLADIIDYIEQYNPVASRKLHQQIVHVAENLPQHPYLYRPGRVAGTREIVVHPNYLVVYHIDDFEIEI
LRVLHARQEYP
VQWVKWKESALNDLADIIDYIEQYNPVASRKLHQQIVHVAENLPQHPYLYRPGRVAGTREIVVHPNYLVVYHIDDFEIEI
LRVLHARQEYP
Download Length: 276 bp
>T229747 NZ_CP124513:3625016-3625234 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 67 a.a. Molecular weight: 7605.66 Da Isoelectric Point: 5.8151
>AT229747 WP_016192654.1 NZ_CP089940:c1347286-1347086 [Erwinia tracheiphila]
MTTKLSPIVSEFETQEQADSYDRWFRAKVQVALDDPRPGIPHDDAMAKLEAMLEERRTLRAKRAMG
MTTKLSPIVSEFETQEQADSYDRWFRAKVQVALDDPRPGIPHDDAMAKLEAMLEERRTLRAKRAMG
Download Length: 201 bp
>AT229747 NZ_CP124513:3624616-3624990 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2KDZ1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2KKT1 |