Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3447376..3448000 Replicon chromosome
Accession NZ_CP089934
Organism Erwinia tracheiphila strain SCR3

Toxin (Protein)


Gene name Hha Uniprot ID A0A0M2K484
Locus tag LU632_RS18245 Protein ID WP_016191644.1
Coordinates 3447782..3448000 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LU632_RS18240 Protein ID WP_233479014.1
Coordinates 3447376..3447756 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU632_RS18220 (LU632_18220) 3442769..3443808 + 1040 Protein_3607 IS481 family transposase -
LU632_RS18225 (LU632_18225) 3444051..3444929 - 879 WP_016191640.1 metal ABC transporter substrate-binding protein -
LU632_RS18230 (LU632_18230) 3444926..3445792 - 867 WP_040465679.1 metal ABC transporter permease -
LU632_RS18235 (LU632_18235) 3445795..3446481 - 687 WP_233479013.1 ABC transporter ATP-binding protein -
LU632_RS18240 (LU632_18240) 3447376..3447756 + 381 WP_233479014.1 Hha toxicity modulator TomB Antitoxin
LU632_RS18245 (LU632_18245) 3447782..3448000 + 219 WP_016191644.1 HHA domain-containing protein Toxin
LU632_RS18255 (LU632_18255) 3448355..3448702 + 348 WP_016191645.1 MGMT family protein -
LU632_RS18260 (LU632_18260) 3448662..3449213 - 552 Protein_3614 YbaY family lipoprotein -
LU632_RS18265 (LU632_18265) 3449474..3450313 + 840 Protein_3615 thioesterase family protein -
LU632_RS18270 (LU632_18270) 3450375..3451679 - 1305 WP_087949710.1 ammonium transporter AmtB -
LU632_RS18275 (LU632_18275) 3451695..3452033 - 339 WP_016191649.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.08 Da        Isoelectric Point: 9.7942

>T229742 WP_016191644.1 NZ_CP089934:3447782-3448000 [Erwinia tracheiphila]
MTNKVLTKTDYLMRLRKCRSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKVPVSVWKFIR

Download         Length: 219 bp

>T229742 NZ_CP124513:2257842-2257944 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14538.11 Da        Isoelectric Point: 4.3117

>AT229742 WP_233479014.1 NZ_CP089934:3447376-3447756 [Erwinia tracheiphila]
MDEYSPKRHDVAQLKFLCENLYDESMTTIGDSHHGWINDPTSASNLQLNDLIEHIASFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGINVQELQRWRKSAEGLFSIFAEECAQVANPASHSF

Download         Length: 381 bp

>AT229742 NZ_CP124513:c2257982-2257714 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2K484

Antitoxin

Source ID Structure

References