Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3238433..3239039 Replicon chromosome
Accession NZ_CP089934
Organism Erwinia tracheiphila strain SCR3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LU632_RS17220 Protein ID WP_233478912.1
Coordinates 3238433..3238612 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LU632_RS17225 Protein ID WP_233478913.1
Coordinates 3238635..3239039 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU632_RS17185 (LU632_17185) 3234165..3234770 - 606 WP_233478907.1 RNA polymerase subunit sigma-70 -
LU632_RS17190 (LU632_17190) 3234956..3235183 + 228 WP_233478908.1 hypothetical protein -
LU632_RS17195 (LU632_17195) 3235218..3236258 - 1041 WP_233478553.1 IS481 family transposase -
LU632_RS17200 (LU632_17200) 3236363..3237235 - 873 WP_233478909.1 phage antirepressor N-terminal domain-containing protein -
LU632_RS17205 (LU632_17205) 3237337..3237510 - 174 WP_233478910.1 Arc family DNA-binding protein -
LU632_RS17210 (LU632_17210) 3237591..3237941 + 351 WP_233478911.1 Arc family DNA-binding protein -
LU632_RS17215 (LU632_17215) 3238085..3238330 + 246 WP_233478880.1 DinI-like family protein -
LU632_RS17220 (LU632_17220) 3238433..3238612 + 180 WP_233478912.1 type II toxin-antitoxin system HicA family toxin Toxin
LU632_RS17225 (LU632_17225) 3238635..3239039 + 405 WP_233478913.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LU632_RS17230 (LU632_17230) 3239076..3239435 + 360 WP_233478914.1 GtrA family protein -
LU632_RS17235 (LU632_17235) 3239432..3240340 + 909 WP_233478915.1 glycosyltransferase family 2 protein -
LU632_RS17240 (LU632_17240) 3240346..3240978 + 633 WP_233478916.1 hypothetical protein -
LU632_RS17245 (LU632_17245) 3241014..3241853 + 840 WP_233478917.1 hypothetical protein -
LU632_RS17250 (LU632_17250) 3241917..3242282 - 366 WP_233478918.1 tail fiber assembly protein -
LU632_RS17260 (LU632_17260) 3243685..3243849 + 165 WP_233478920.1 hypothetical protein -
LU632_RS17265 (LU632_17265) 3243855..3244028 - 174 WP_233478921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gtrB / gtrB 3199754..3247134 47380
- flank IS/Tn - - 3235218..3236258 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6649.79 Da        Isoelectric Point: 10.9132

>T229741 WP_233478912.1 NZ_CP089934:3238433-3238612 [Erwinia tracheiphila]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHSQKDIPQPTLKSIKKQAGL

Download         Length: 180 bp

>T229741 NZ_CP124513:c2013987-2013613 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14615.53 Da        Isoelectric Point: 4.1880

>AT229741 WP_233478913.1 NZ_CP089934:3238635-3239039 [Erwinia tracheiphila]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLVEDGEGLPEATSVENWLADPDYVDVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGRI

Download         Length: 405 bp

>AT229741 NZ_CP124513:c2014444-2014076 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References