Detailed information of TA system TA229731

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1407887..1408406
• Replicon: chromosome
• Accession: NZ_CP089934
• Organism: Erwinia tracheiphila strain SCR3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LU632_RS07465
• Protein ID: WP_233480300.1
• Coordinates: 1408122..1408406 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1X0W393
• Locus tag: LU632_RS07460
• Protein ID: WP_008815935.1
• Coordinates: 1407887..1408129 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LU632_RS07435 (LU632_07435)	1403140..1403234	-	95	Protein_1467	IS6 family transposase	-
LU632_RS07440 (LU632_07440)	1403866..1404234	+	369	WP_233480299.1	hypothetical protein	-
LU632_RS07445 (LU632_07445)	1404394..1404621	-	228	Protein_1469	DDE-type integrase/transposase/recombinase	-
LU632_RS26350	1405182..1405862	+	681	WP_252120230.1	transposase zinc-binding domain-containing protein	-
LU632_RS26355	1405859..1406404	+	546	WP_252120243.1	transposase	-
LU632_RS07455 (LU632_07455)	1406548..1406874	+	327	Protein_1472	incFII family plasmid replication initiator RepA	-
LU632_RS07460 (LU632_07460)	1407887..1408129	+	243	WP_008815935.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LU632_RS07465 (LU632_07465)	1408122..1408406	+	285	WP_233480300.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LU632_RS07470 (LU632_07470)	1408566..1408856	-	291	WP_233480301.1	hypothetical protein	-
LU632_RS07475 (LU632_07475)	1408853..1409008	-	156	Protein_1476	recombinase family protein	-
LU632_RS07480 (LU632_07480)	1409058..1409546	+	489	WP_233480753.1	phage tail protein	-
LU632_RS07485 (LU632_07485)	1409546..1410142	+	597	WP_016191668.1	tail fiber assembly protein	-
LU632_RS07490 (LU632_07490)	1410117..1410725	-	609	WP_016191669.1	tail assembly chaperone	-
LU632_RS07495 (LU632_07495)	1410725..1411639	-	915	WP_233480302.1	tail fiber protein	-
LU632_RS07500 (LU632_07500)	1411642..1412220	-	579	WP_233480303.1	phage tail protein I	-
LU632_RS07505 (LU632_07505)	1412213..1413316	-	1104	WP_016191672.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1300291..1445454	145163

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-88)

Antitoxin

• Antitoxin ParD (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11067.59 Da
• Isoelectric Point: 6.3252

>T229731 WP_233480300.1 NZ_CP089934:1408122-1408406 [Erwinia tracheiphila]
VYKLTERAAEDFAGIYDYTLLKFGEAQADHYTDALEAFFETLSGMPDMGRDYNAVPGVMRIEFQRHIIFYTVRDTDILIA
RILHQQMNHKRHLR

Nucleotide

• Length: 285 bp

>T229731 NZ_CP124512:c115588-115283 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8860.98 Da
• Isoelectric Point: 7.0130

>AT229731 WP_008815935.1 NZ_CP089934:1407887-1408129 [Erwinia tracheiphila]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVVRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Nucleotide

• Length: 243 bp

>AT229731 NZ_CP124512:c115808-115590 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1X0W393