Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1130212..1130860 Replicon chromosome
Accession NZ_CP089934
Organism Erwinia tracheiphila strain SCR3

Toxin (Protein)


Gene name cptA Uniprot ID A0A0M2KDQ7
Locus tag LU632_RS05965 Protein ID WP_016190246.1
Coordinates 1130459..1130860 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0M2KLB4
Locus tag LU632_RS05960 Protein ID WP_016190247.1
Coordinates 1130212..1130478 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU632_RS05930 (LU632_05930) 1125586..1127025 - 1440 WP_233480154.1 6-phospho-beta-glucosidase -
LU632_RS05935 (LU632_05935) 1127219..1127689 - 471 Protein_1173 PTS transporter subunit EIIB -
LU632_RS05940 (LU632_05940) 1127704..1128094 + 391 Protein_1174 hemolysin III family protein -
LU632_RS05945 (LU632_05945) 1128144..1128841 + 698 WP_233480155.1 IS1 family transposase -
LU632_RS05950 (LU632_05950) 1128863..1128973 + 111 Protein_1176 hemolysin III family protein -
LU632_RS05955 (LU632_05955) 1129015..1129995 - 981 WP_233480156.1 tRNA-modifying protein YgfZ -
LU632_RS05960 (LU632_05960) 1130212..1130478 + 267 WP_016190247.1 FAD assembly factor SdhE Antitoxin
LU632_RS05965 (LU632_05965) 1130459..1130860 + 402 WP_016190246.1 protein YgfX Toxin
LU632_RS05970 (LU632_05970) 1130970..1131488 - 519 WP_233480157.1 flavodoxin FldB -
LU632_RS05975 (LU632_05975) 1131587..1132480 + 894 WP_016190244.1 site-specific tyrosine recombinase XerD -
LU632_RS05980 (LU632_05980) 1132524..1133228 + 705 WP_016190243.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LU632_RS05985 (LU632_05985) 1133234..1134952 + 1719 WP_233480158.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hsiB1/vipA / hsiC1/vipB 746125..1186476 440351
- flank IS/Tn - - 1128338..1128841 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-130)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15786.53 Da        Isoelectric Point: 12.0140

>T229730 WP_016190246.1 NZ_CP089934:1130459-1130860 [Erwinia tracheiphila]
VALWHSELRVSWRAQWFSLLLHGVAILIVLLAPWPASYTVVWMSLLTLTIFECVRSQRRIGNREGEIALFEGRQVQWRQK
RWQIRGRPWITRQAILMTLRSATGEREKLWLFSDSMSAEDWRSLRKQLLRAAL

Download         Length: 402 bp

>T229730 NZ_CP124511:c4978749-4978375 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10492.04 Da        Isoelectric Point: 4.8102

>AT229730 WP_016190247.1 NZ_CP089934:1130212-1130478 [Erwinia tracheiphila]
MDISNKARVHWACRRGMRELDISIMPFFEYEYDSLSDSDKLVFVRLLENDDPDLFNWLMNYGEPPDTELKRMVLLIQQRN
KQRGPVAL

Download         Length: 267 bp

>AT229730 NZ_CP124511:c4979206-4978838 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2KDQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2KLB4

References