Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1210967..1211652 | Replicon | chromosome |
| Accession | NC_011035 | ||
| Organism | Neisseria gonorrhoeae NCCP11945 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | NGK_RS06545 | Protein ID | WP_003689143.1 |
| Coordinates | 1210967..1211149 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | NGK_RS06550 | Protein ID | WP_003691454.1 |
| Coordinates | 1211251..1211652 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NGK_RS06510 | 1205973..1206872 | - | 900 | WP_041421306.1 | replication protein | - |
| NGK_RS15435 | 1207069..1207269 | - | 201 | WP_012503750.1 | hypothetical protein | - |
| NGK_RS06520 | 1207271..1207456 | - | 186 | WP_048654326.1 | helix-turn-helix domain-containing protein | - |
| NGK_RS12245 | 1207621..1208307 | + | 687 | WP_012503751.1 | helix-turn-helix transcriptional regulator | - |
| NGK_RS06530 | 1208347..1209045 | + | 699 | WP_002212401.1 | helix-turn-helix domain-containing protein | - |
| NGK_RS06535 | 1209284..1209982 | + | 699 | WP_003689139.1 | hypothetical protein | - |
| NGK_RS06540 | 1209979..1210797 | + | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| NGK_RS06545 | 1210967..1211149 | + | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| NGK_RS06550 | 1211251..1211652 | + | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| NGK_RS06555 | 1211751..1212533 | - | 783 | WP_003689146.1 | hypothetical protein | - |
| NGK_RS06560 | 1212733..1212933 | + | 201 | WP_003704298.1 | hypothetical protein | - |
| NGK_RS06565 | 1212966..1213442 | + | 477 | WP_002255718.1 | hypothetical protein | - |
| NGK_RS06570 | 1213439..1213726 | + | 288 | WP_041421246.1 | hypothetical protein | - |
| NGK_RS06575 | 1213867..1214199 | + | 333 | WP_003687946.1 | hypothetical protein | - |
| NGK_RS06580 | 1214352..1214630 | + | 279 | WP_041421244.1 | hypothetical protein | - |
| NGK_RS06585 | 1214627..1214788 | + | 162 | WP_003691530.1 | hypothetical protein | - |
| NGK_RS06590 | 1214857..1215543 | + | 687 | WP_012503754.1 | hypothetical protein | - |
| NGK_RS06595 | 1215683..1215865 | + | 183 | WP_003691535.1 | hypothetical protein | - |
| NGK_RS06600 | 1215862..1216353 | + | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| NGK_RS06605 | 1216405..1216620 | + | 216 | WP_003691538.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1163221..1232748 | 69527 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T22973 WP_003689143.1 NC_011035:1210967-1211149 [Neisseria gonorrhoeae NCCP11945]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T22973 NC_011035:1210967-1211149 [Neisseria gonorrhoeae NCCP11945]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT22973 WP_003691454.1 NC_011035:1211251-1211652 [Neisseria gonorrhoeae NCCP11945]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT22973 NC_011035:1211251-1211652 [Neisseria gonorrhoeae NCCP11945]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|