Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 314151..314752 Replicon chromosome
Accession NZ_CP089934
Organism Erwinia tracheiphila strain SCR3

Toxin (Protein)


Gene name doc Uniprot ID A0A0M2K9A2
Locus tag LU632_RS01570 Protein ID WP_046371846.1
Coordinates 314369..314752 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID H3R939
Locus tag LU632_RS01565 Protein ID WP_006117881.1
Coordinates 314151..314372 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU632_RS01535 (LU632_01535) 309183..309566 + 384 WP_016193222.1 hypothetical protein -
LU632_RS01540 (LU632_01540) 309566..312061 + 2496 WP_052734703.1 replication endonuclease -
LU632_RS01545 (LU632_01545) 312027..312452 + 426 WP_233479718.1 hypothetical protein -
LU632_RS01550 (LU632_01550) 312508..312783 + 276 WP_233479719.1 type II toxin-antitoxin system HicA family toxin -
LU632_RS01555 (LU632_01555) 312780..313139 + 360 WP_046371849.1 type II toxin-antitoxin system HicB family antitoxin -
LU632_RS01560 (LU632_01560) 313389..314084 + 696 WP_233479720.1 DNA adenine methylase -
LU632_RS01565 (LU632_01565) 314151..314372 + 222 WP_006117881.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LU632_RS01570 (LU632_01570) 314369..314752 + 384 WP_046371846.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LU632_RS01575 (LU632_01575) 315238..315741 + 504 WP_233479721.1 hypothetical protein -
LU632_RS01580 (LU632_01580) 315812..316870 - 1059 WP_233479722.1 phage portal protein -
LU632_RS01585 (LU632_01585) 316870..318600 - 1731 WP_233479723.1 terminase family protein -
LU632_RS01590 (LU632_01590) 318761..319597 + 837 WP_016193215.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 301719..353787 52068


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14129.14 Da        Isoelectric Point: 4.9094

>T229728 WP_046371846.1 NZ_CP089934:314369-314752 [Erwinia tracheiphila]
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH

Download         Length: 384 bp

>T229728 NZ_CP124511:4965465-4965716 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8110.06 Da        Isoelectric Point: 5.0644

>AT229728 WP_006117881.1 NZ_CP089934:314151-314372 [Erwinia tracheiphila]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR

Download         Length: 222 bp

>AT229728 NZ_CP124511:4965713-4965967 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2K9A2

Antitoxin

Source ID Structure
AlphaFold DB A0A068Z6U5

References