Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 3686392..3686993 | Replicon | chromosome |
| Accession | NZ_CP089932 | ||
| Organism | Erwinia tracheiphila strain BHKY | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A0M2K9A2 |
| Locus tag | LU633_RS19160 | Protein ID | WP_046371846.1 |
| Coordinates | 3686392..3686775 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | H3R939 |
| Locus tag | LU633_RS19165 | Protein ID | WP_006117881.1 |
| Coordinates | 3686772..3686993 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LU633_RS19135 (LU633_19135) | 3681444..3681584 | + | 141 | WP_161796965.1 | hypothetical protein | - |
| LU633_RS19140 (LU633_19140) | 3681593..3682807 | + | 1215 | WP_046371879.1 | IS91 family transposase | - |
| LU633_RS19145 (LU633_19145) | 3682959..3684350 | + | 1392 | Protein_3772 | terminase family protein | - |
| LU633_RS19150 (LU633_19150) | 3684350..3685408 | + | 1059 | WP_046371980.1 | phage portal protein | - |
| LU633_RS19155 (LU633_19155) | 3685479..3685982 | - | 504 | WP_016193219.1 | hypothetical protein | - |
| LU633_RS19160 (LU633_19160) | 3686392..3686775 | - | 384 | WP_046371846.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LU633_RS19165 (LU633_19165) | 3686772..3686993 | - | 222 | WP_006117881.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LU633_RS19170 (LU633_19170) | 3687060..3687755 | - | 696 | WP_046371847.1 | DNA methylase | - |
| LU633_RS19175 (LU633_19175) | 3688005..3688364 | - | 360 | WP_046371849.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LU633_RS19180 (LU633_19180) | 3688384..3688650 | - | 267 | WP_046371850.1 | hypothetical protein | - |
| LU633_RS19185 (LU633_19185) | 3688616..3691111 | - | 2496 | WP_052734703.1 | replication endonuclease | - |
| LU633_RS19190 (LU633_19190) | 3691111..3691494 | - | 384 | WP_046371981.1 | hypothetical protein | - |
| LU633_RS19195 (LU633_19195) | 3691567..3691809 | - | 243 | WP_016193223.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3665016..3741155 | 76139 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14129.14 Da Isoelectric Point: 4.9094
>T229723 WP_046371846.1 NZ_CP089932:c3686775-3686392 [Erwinia tracheiphila]
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH
MKWISAQEVIAFHDRLLTALPGVQGMPEPGRAEAIIYRVQNQLYYEGVEDIHELAAMYLVAISRGHIFNDGNKRTAFFVA
MAFLKRNGIDIRDEGDELEELTVSAAMGAVSSDDIAAVLRRLSINPH
Download Length: 384 bp
>T229723 NZ_CP124511:3257768-3258295 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8110.06 Da Isoelectric Point: 5.0644
>AT229723 WP_006117881.1 NZ_CP089932:c3686993-3686772 [Erwinia tracheiphila]
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR
MRTYTTSQARQNIAEVMEAATAGEPVEITRRDGSAAVLISRDDFNAWQEAKLDAEFAEIMGRHGRTIKALADR
Download Length: 222 bp
>AT229723 NZ_CP124511:3257495-3257761 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2K9A2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A068Z6U5 |