229722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3612600..3613248 Replicon chromosome
Accession NZ_CP089932
Organism Erwinia tracheiphila strain BHKY

Toxin (Protein)


Gene name cptA Uniprot ID A0A0M2KDQ7
Locus tag LU633_RS18780 Protein ID WP_016190246.1
Coordinates 3612600..3613001 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0M2KLB4
Locus tag LU633_RS18785 Protein ID WP_016190247.1
Coordinates 3612982..3613248 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU633_RS18760 (LU633_18760) 3608508..3610226 - 1719 WP_016190242.1 single-stranded-DNA-specific exonuclease RecJ -
LU633_RS18765 (LU633_18765) 3610232..3610936 - 705 WP_016190243.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LU633_RS18770 (LU633_18770) 3610980..3611873 - 894 WP_016190244.1 site-specific tyrosine recombinase XerD -
LU633_RS18775 (LU633_18775) 3611972..3612490 + 519 WP_016190245.1 flavodoxin FldB -
LU633_RS18780 (LU633_18780) 3612600..3613001 - 402 WP_016190246.1 protein YgfX Toxin
LU633_RS18785 (LU633_18785) 3612982..3613248 - 267 WP_016190247.1 FAD assembly factor SdhE Antitoxin
LU633_RS18790 (LU633_18790) 3613465..3614445 + 981 WP_016190248.1 tRNA-modifying protein YgfZ -
LU633_RS18795 (LU633_18795) 3614487..3614597 - 111 Protein_3704 hemolysin III family protein -
LU633_RS18800 (LU633_18800) 3614619..3615122 - 504 WP_046371978.1 IS1 family transposase -
LU633_RS18810 (LU633_18810) 3615366..3615756 - 391 Protein_3706 hemolysin III family protein -
LU633_RS18815 (LU633_18815) 3615771..3616241 + 471 Protein_3707 PTS transporter subunit EIIB -
LU633_RS18820 (LU633_18820) 3616435..3617874 + 1440 WP_016190252.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3614619..3615122 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-130)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15786.53 Da        Isoelectric Point: 12.0140

>T229722 WP_016190246.1 NZ_CP089932:c3613001-3612600 [Erwinia tracheiphila]
VALWHSELRVSWRAQWFSLLLHGVAILIVLLAPWPASYTVVWMSLLTLTIFECVRSQRRIGNREGEIALFEGRQVQWRQK
RWQIRGRPWITRQAILMTLRSATGEREKLWLFSDSMSAEDWRSLRKQLLRAAL

Download         Length: 402 bp

>T229722 NZ_CP124511:3155257-3155364 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10492.04 Da        Isoelectric Point: 4.8102

>AT229722 WP_016190247.1 NZ_CP089932:c3613248-3612982 [Erwinia tracheiphila]
MDISNKARVHWACRRGMRELDISIMPFFEYEYDSLSDSDKLVFVRLLENDDPDLFNWLMNYGEPPDTELKRMVLLIQQRN
KQRGPVAL

Download         Length: 267 bp

>AT229722 NZ_CP124511:c3155200-3155143 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2KDQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2KLB4

References