Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 725784..726439 Replicon chromosome
Accession NC_011035
Organism Neisseria gonorrhoeae NCCP11945

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NGK_RS04010 Protein ID WP_003691083.1
Coordinates 726020..726439 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NGK_RS04005 Protein ID WP_003688410.1
Coordinates 725784..726020 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK_RS03975 720918..721205 + 288 WP_003688407.1 hypothetical protein -
NGK_RS03980 721277..722443 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NGK_RS03985 722454..723344 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NGK_RS03990 723727..724113 - 387 Protein_746 IS110 family transposase -
NGK_RS03995 724325..724753 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
NGK_RS04000 724758..725336 + 579 WP_003688041.1 IS3 family transposase -
NGK_RS14320 725381..725578 + 198 WP_033910354.1 IS3 family transposase -
NGK_RS04005 725784..726020 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NGK_RS04010 726020..726439 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NGK_RS04015 726588..728042 - 1455 WP_003701282.1 iron-sulfur cluster-binding protein -
NGK_RS04020 728039..728740 - 702 WP_003688414.1 lactate utilization protein C -
NGK_RS04025 728737..729516 - 780 WP_041421436.1 (Fe-S)-binding protein -
NGK_RS04030 729664..731205 + 1542 WP_003697015.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T22972 WP_003691083.1 NC_011035:726020-726439 [Neisseria gonorrhoeae NCCP11945]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T22972 NC_011035:726020-726439 [Neisseria gonorrhoeae NCCP11945]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT22972 WP_003688410.1 NC_011035:725784-726020 [Neisseria gonorrhoeae NCCP11945]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT22972 NC_011035:725784-726020 [Neisseria gonorrhoeae NCCP11945]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References