Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1309173..1309796 Replicon chromosome
Accession NZ_CP089932
Organism Erwinia tracheiphila strain BHKY

Toxin (Protein)


Gene name Hha Uniprot ID A0A0M2K484
Locus tag LU633_RS06900 Protein ID WP_016191644.1
Coordinates 1309173..1309391 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0M2KB13
Locus tag LU633_RS06905 Protein ID WP_016191643.1
Coordinates 1309416..1309796 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU633_RS06870 (LU633_06870) 1305140..1305478 + 339 WP_016191649.1 P-II family nitrogen regulator -
LU633_RS06875 (LU633_06875) 1305494..1306798 + 1305 WP_087949710.1 ammonium transporter AmtB -
LU633_RS06880 (LU633_06880) 1306860..1307699 - 840 Protein_1352 thioesterase family protein -
LU633_RS06885 (LU633_06885) 1307952..1308511 + 560 Protein_1353 YbaY family lipoprotein -
LU633_RS06890 (LU633_06890) 1308471..1308818 - 348 WP_016191645.1 MGMT family protein -
LU633_RS06900 (LU633_06900) 1309173..1309391 - 219 WP_016191644.1 HHA domain-containing protein Toxin
LU633_RS06905 (LU633_06905) 1309416..1309796 - 381 WP_016191643.1 Hha toxicity modulator TomB Antitoxin
LU633_RS06910 (LU633_06910) 1310691..1311377 + 687 WP_046372383.1 ABC transporter ATP-binding protein -
LU633_RS06915 (LU633_06915) 1311380..1312246 + 867 WP_040465679.1 metal ABC transporter permease -
LU633_RS06920 (LU633_06920) 1312243..1313121 + 879 WP_016191640.1 metal ABC transporter substrate-binding protein -
LU633_RS06925 (LU633_06925) 1313364..1314403 - 1040 Protein_1360 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - acrB / acrA 1097824..1418700 320876


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.08 Da        Isoelectric Point: 9.7942

>T229711 WP_016191644.1 NZ_CP089932:c1309391-1309173 [Erwinia tracheiphila]
MTNKVLTKTDYLMRLRKCRSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKVPVSVWKFIR

Download         Length: 219 bp

>T229711 NZ_CP124511:423439-424761 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14552.13 Da        Isoelectric Point: 4.3117

>AT229711 WP_016191643.1 NZ_CP089932:c1309796-1309416 [Erwinia tracheiphila]
MDEYSPKRHDIAQLKFLCENLYDESMTTIGDSHHGWINDPTSASNLQLNDLIEHIASFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGINVQELQRWRKSAEGLFSIFAEECAQVANPASHSF

Download         Length: 381 bp

>AT229711 NZ_CP124511:423173-423439 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2K484

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2KB13

References