Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1098399..1098861 | Replicon | chromosome |
| Accession | NZ_CP089932 | ||
| Organism | Erwinia tracheiphila strain BHKY | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0M2KDZ1 |
| Locus tag | LU633_RS05585 | Protein ID | WP_016192653.1 |
| Coordinates | 1098399..1098674 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0M2KKT1 |
| Locus tag | LU633_RS05590 | Protein ID | WP_016192654.1 |
| Coordinates | 1098661..1098861 (-) | Length | 67 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LU633_RS05555 (LU633_05555) | 1093568..1094788 | - | 1221 | WP_046371806.1 | ISL3 family transposase | - |
| LU633_RS05560 (LU633_05560) | 1094894..1095055 | - | 162 | WP_161796998.1 | hypothetical protein | - |
| LU633_RS05565 (LU633_05565) | 1095069..1095245 | - | 177 | WP_161796999.1 | hypothetical protein | - |
| LU633_RS05570 (LU633_05570) | 1095508..1096104 | - | 597 | WP_016193254.1 | YhgN family NAAT transporter | - |
| LU633_RS05575 (LU633_05575) | 1096372..1097481 | + | 1110 | WP_016193253.1 | aspartate-semialdehyde dehydrogenase | - |
| LU633_RS05580 (LU633_05580) | 1097574..1098271 | + | 698 | WP_233481998.1 | IS1 family transposase | - |
| LU633_RS05585 (LU633_05585) | 1098399..1098674 | - | 276 | WP_016192653.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| LU633_RS05590 (LU633_05590) | 1098661..1098861 | - | 201 | WP_016192654.1 | hypothetical protein | Antitoxin |
| LU633_RS05595 (LU633_05595) | 1099158..1099511 | + | 354 | WP_016192655.1 | RAQPRD family integrative conjugative element protein | - |
| LU633_RS05600 (LU633_05600) | 1099512..1099640 | + | 129 | WP_016192656.1 | DUF3262 family protein | - |
| LU633_RS05605 (LU633_05605) | 1099677..1100054 | + | 378 | WP_016192657.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| LU633_RS05610 (LU633_05610) | 1100066..1100155 | + | 90 | Protein_1097 | DUF3487 family protein | - |
| LU633_RS05615 (LU633_05615) | 1100241..1101119 | + | 879 | WP_016192659.1 | TIGR03749 family integrating conjugative element protein | - |
| LU633_RS05620 (LU633_05620) | 1101116..1102630 | + | 1515 | WP_152664262.1 | TIGR03752 family integrating conjugative element protein | - |
| LU633_RS05625 (LU633_05625) | 1102642..1102902 | + | 261 | WP_016193251.1 | hypothetical protein | - |
| LU633_RS05630 (LU633_05630) | 1102889..1103293 | + | 405 | WP_016193250.1 | TIGR03751 family conjugal transfer lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | acrB / acrA | 1097824..1418700 | 320876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10828.34 Da Isoelectric Point: 6.4863
>T229710 WP_016192653.1 NZ_CP089932:c1098674-1098399 [Erwinia tracheiphila]
VQWVKWKESALNDLADIIDYIEQYNPVASRKLHQQIVHVAENLPQHPYLYRPGRVAGTREIVVHPNYLVVYHIDDFEIEI
LRVLHARQEYP
VQWVKWKESALNDLADIIDYIEQYNPVASRKLHQQIVHVAENLPQHPYLYRPGRVAGTREIVVHPNYLVVYHIDDFEIEI
LRVLHARQEYP
Download Length: 276 bp
>T229710 NZ_CP124511:141688-141790 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 67 a.a. Molecular weight: 7605.66 Da Isoelectric Point: 5.8151
>AT229710 WP_016192654.1 NZ_CP089932:c1098861-1098661 [Erwinia tracheiphila]
MTTKLSPIVSEFETQEQADSYDRWFRAKVQVALDDPRPGIPHDDAMAKLEAMLEERRTLRAKRAMG
MTTKLSPIVSEFETQEQADSYDRWFRAKVQVALDDPRPGIPHDDAMAKLEAMLEERRTLRAKRAMG
Download Length: 201 bp
>AT229710 NZ_CP124511:c141828-141560 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2KDZ1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2KKT1 |