Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 578704..579851 Replicon chromosome
Accession NZ_CP089928
Organism Microbulbifer sp. YPW16

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LVE68_RS02505 Protein ID WP_232942822.1
Coordinates 578704..579489 (-) Length 262 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LVE68_RS02510 Protein ID WP_232942823.1
Coordinates 579486..579851 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVE68_RS02480 (LVE68_02480) 574021..575133 - 1113 WP_232942817.1 dTDP-glucose 4,6-dehydratase -
LVE68_RS02485 (LVE68_02485) 575184..576092 - 909 WP_232942818.1 dTDP-4-dehydrorhamnose reductase -
LVE68_RS02490 (LVE68_02490) 576111..576668 - 558 WP_232942819.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
LVE68_RS02495 (LVE68_02495) 576671..577549 - 879 WP_232942820.1 glucose-1-phosphate thymidylyltransferase RfbA -
LVE68_RS02500 (LVE68_02500) 577699..578634 - 936 WP_232942821.1 pyridoxal-phosphate dependent enzyme -
LVE68_RS02505 (LVE68_02505) 578704..579489 - 786 WP_232942822.1 RES family NAD+ phosphorylase Toxin
LVE68_RS02510 (LVE68_02510) 579486..579851 - 366 WP_232942823.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
LVE68_RS02515 (LVE68_02515) 580076..581056 + 981 WP_232942824.1 zinc-dependent alcohol dehydrogenase family protein -
LVE68_RS02520 (LVE68_02520) 581179..583137 - 1959 WP_233006758.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 550200..583137 32937


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(61-221)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(11-67)


Sequences

Toxin        


Download         Length: 262 a.a.        Molecular weight: 28808.68 Da        Isoelectric Point: 6.8775

>T229709 WP_232942822.1 NZ_CP089928:c579489-578704 [Microbulbifer sp. YPW16]
MSDGLGQLIDNSRQRLMGRLFRMVESQEDVATRSLVDSLQKQEALENLLERSKPKRLPGTEQLHYLLATPFRYPPLPWGS
RFGSTAENGIFYGSKTIPTVLAESAYYRQLFFNDMEIPPAVPITSYHSIFSARYAADPGVRLQAPDWESHWDRIADPVNY
SFCQQLGARMRASGIVGIEAPSARARQAGISPFPPTDSEGVNVALFSPEVLLRRAPMQEAEVTAETGADGVAFLLKLGDG
TVTHRFPATAFRVGGRLPQPA

Download         Length: 786 bp

>T229709 NZ_CP124510:c63122-62742 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13357.50 Da        Isoelectric Point: 7.2036

>AT229709 WP_232942823.1 NZ_CP089928:c579851-579486 [Microbulbifer sp. YPW16]
MASMPSLEPQPAEDEVLLEALLNTASYLGLRKRELADIIHMDERTLRRKSGLAPDSAPGQLALLLVRAYRAAFVLMGGAE
GARHWFDTPNKSLNGTPREMVVQIEGLVRVVNYLDAMRGKV

Download         Length: 366 bp

>AT229709 NZ_CP124510:c63343-63122 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTAGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References