Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4051211..4051860 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag LV451_RS18975 Protein ID WP_003403236.1
Coordinates 4051465..4051860 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag LV451_RS18970 Protein ID WP_003403235.1
Coordinates 4051211..4051465 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS18945 4046337..4046420 + 84 Protein_3746 galactose-1-phosphate uridylyltransferase -
LV451_RS18950 4046439..4047520 + 1082 Protein_3747 galactose-1-phosphate uridylyltransferase -
LV451_RS18955 4047517..4048608 + 1092 WP_003906403.1 galactokinase -
LV451_RS18960 4049003..4050067 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LV451_RS18965 4050171..4051118 + 948 WP_003403232.1 DUF732 domain-containing protein -
LV451_RS18970 4051211..4051465 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
LV451_RS18975 4051465..4051860 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
LV451_RS18980 4051954..4052694 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
LV451_RS18985 4052826..4053086 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LV451_RS18990 4053083..4053490 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
LV451_RS18995 4053562..4054713 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
LV451_RS19000 4054806..4056533 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T229700 WP_003403236.1 NZ_CP089927:4051465-4051860 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T229700 NZ_CP124508:c3517767-3517465 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT229700 WP_003403235.1 NZ_CP089927:4051211-4051465 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT229700 NZ_CP124508:c3517429-3517088 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References