Detailed information of TA system TA022970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 402707..403344
• Replicon: chromosome
• Accession: NC_011027
• Organism: Chlorobaculum parvum NCIB 8327

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B3QL13
• Locus tag: CPAR_RS01950
• Protein ID: WP_012501634.1
• Coordinates: 402937..403344 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B3QL12
• Locus tag: CPAR_RS01945
• Protein ID: WP_012501633.1
• Coordinates: 402707..402940 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPAR_RS01920	397763..398212	+	450	WP_012501628.1	D-tyrosyl-tRNA(Tyr) deacylase	-
CPAR_RS01925	398331..399077	+	747	WP_012501629.1	3-deoxy-manno-octulosonate cytidylyltransferase	-
CPAR_RS01930	399055..400263	-	1209	WP_012501630.1	exodeoxyribonuclease VII large subunit	-
CPAR_RS01935	400386..401390	+	1005	WP_012501631.1	SPOR domain-containing protein	-
CPAR_RS01940	401371..402618	+	1248	WP_012501632.1	chlorophyllide a reductase subunit Y	-
CPAR_RS01945	402707..402940	+	234	WP_012501633.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CPAR_RS01950	402937..403344	+	408	WP_012501634.1	type II toxin-antitoxin system VapC family toxin	Toxin
CPAR_RS01955	403593..404702	-	1110	WP_012501635.1	DGQHR domain-containing protein	-
CPAR_RS01960	404714..405211	-	498	WP_012501636.1	hypothetical protein	-
CPAR_RS01965	405215..406084	-	870	WP_012501637.1	Dam family site-specific DNA-(adenine-N6)-methyltransferase	-
CPAR_RS01970	406081..406413	-	333	WP_156773343.1	hypothetical protein	-
CPAR_RS01975	406564..407124	-	561	WP_012501638.1	ribosome recycling factor	-
CPAR_RS01980	407159..407383	-	225	WP_012501639.1	50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (7-40)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15083.37 Da
• Isoelectric Point: 6.7211

>T22970 WP_012501634.1 NC_011027:402937-403344 [Chlorobaculum parvum NCIB 8327]
MIYLLDTNICIYIINQKPPHVLERFRRERLGDIAISSVTASELTFGVVKSGSEKNRQALALFFAPLEILPFDASVIWHYG
EIRSDLEKRGTPIGSLDTMIAAHARALGAVLVTNNVREFSRVEGLRVENWAELSG

Nucleotide

• Length: 408 bp

>T22970 NC_011027:402937-403344 [Chlorobaculum parvum NCIB 8327]
ATGATCTATCTGCTCGACACCAACATCTGCATCTACATTATCAACCAGAAACCGCCTCACGTTCTCGAACGCTTTCGCCG
CGAGAGGTTGGGAGATATTGCCATATCGAGCGTTACGGCTTCGGAGCTGACTTTTGGCGTCGTCAAAAGCGGTTCAGAGA
AGAACCGGCAAGCGCTGGCTTTGTTCTTTGCTCCACTCGAAATCCTGCCGTTCGATGCTTCCGTGATCTGGCATTACGGA
GAGATCAGAAGCGACCTCGAAAAGCGCGGCACTCCGATCGGCTCCCTCGACACCATGATCGCCGCCCACGCCAGAGCGCT
CGGCGCAGTGCTGGTAACGAACAACGTCAGGGAGTTCAGCAGGGTTGAAGGATTACGGGTGGAGAACTGGGCGGAGTTGT
CTGGGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8865.12 Da
• Isoelectric Point: 5.1314

>AT22970 WP_012501633.1 NC_011027:402707-402940 [Chlorobaculum parvum NCIB 8327]
MDTAKIFTSGRSQAVRLPKEYRFEGKEVIVRHFGNGVILLPCDKPWDMLEAALNEFEPGFQLVREQPETQSREEIKG

Nucleotide

• Length: 234 bp

>AT22970 NC_011027:402707-402940 [Chlorobaculum parvum NCIB 8327]
ATGGACACAGCGAAAATATTTACCTCGGGTCGCAGTCAGGCGGTTCGGTTGCCGAAAGAGTATCGGTTCGAGGGCAAAGA
GGTGATTGTCCGGCATTTTGGCAACGGTGTCATTCTTCTGCCCTGTGACAAGCCTTGGGATATGCTCGAAGCGGCTTTGA
ACGAGTTTGAACCCGGCTTTCAGCTTGTGCGTGAGCAGCCGGAGACGCAAAGCCGCGAGGAGATCAAGGGATGA

Structures

Toxin

• AlphaFold DB: B3QL13

Antitoxin

• AlphaFold DB: B3QL12