Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4045583..4046208 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LV451_RS18940 Protein ID WP_003403218.1
Coordinates 4045807..4046208 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LV451_RS18935 Protein ID WP_003403213.1
Coordinates 4045583..4045810 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS18910 4040762..4040983 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LV451_RS18915 4041125..4041730 + 606 WP_003898526.1 hypothetical protein -
LV451_RS18920 4041749..4044316 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
LV451_RS18925 4044400..4045149 + 750 WP_003898528.1 hypothetical protein -
LV451_RS18930 4045146..4045388 + 243 WP_003403210.1 hypothetical protein -
LV451_RS18935 4045583..4045810 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LV451_RS18940 4045807..4046208 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LV451_RS18945 4046337..4046420 + 84 Protein_3746 galactose-1-phosphate uridylyltransferase -
LV451_RS18950 4046439..4047520 + 1082 Protein_3747 galactose-1-phosphate uridylyltransferase -
LV451_RS18955 4047517..4048608 + 1092 WP_003906403.1 galactokinase -
LV451_RS18960 4049003..4050067 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LV451_RS18965 4050171..4051118 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T229699 WP_003403218.1 NZ_CP089927:4045807-4046208 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T229699 NZ_CP124508:2878488-2878766 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT229699 WP_003403213.1 NZ_CP089927:4045583-4045810 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT229699 NZ_CP124508:2878295-2878486 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References