Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4038045..4038688 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LV451_RS18890 Protein ID WP_003403187.1
Coordinates 4038287..4038688 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LV451_RS18885 Protein ID WP_003403184.1
Coordinates 4038045..4038290 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS18850 4033325..4033855 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LV451_RS18855 4033839..4034534 - 696 WP_003918099.1 two-component system response regulator TcrA -
LV451_RS18860 4034657..4034968 + 312 WP_003403164.1 hypothetical protein -
LV451_RS18865 4035040..4035990 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LV451_RS18870 4036231..4036815 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LV451_RS18875 4036817..4037527 + 711 Protein_3732 IS607 family element RNA-guided endonuclease TnpB -
LV451_RS18880 4037530..4038000 + 471 WP_003898523.1 hypothetical protein -
LV451_RS18885 4038045..4038290 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LV451_RS18890 4038287..4038688 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LV451_RS18895 4038679..4038858 + 180 Protein_3736 hypothetical protein -
LV451_RS18900 4039276..4039473 - 198 WP_003403191.1 hypothetical protein -
LV451_RS18905 4039553..4040710 - 1158 WP_003898524.1 hypothetical protein -
LV451_RS18910 4040762..4040983 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LV451_RS18915 4041125..4041730 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T229698 WP_003403187.1 NZ_CP089927:4038287-4038688 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T229698 NZ_CP124508:2715852-2715959 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT229698 WP_003403184.1 NZ_CP089927:4038045-4038290 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT229698 NZ_CP124508:c2715795-2715740 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References