Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2697459..2697988 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag LV451_RS12760 Protein ID WP_003417760.1
Coordinates 2697731..2697988 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag LV451_RS12755 Protein ID WP_003417757.1
Coordinates 2697459..2697734 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS12720 2694032..2694721 - 690 WP_003917774.1 BBE domain-containing protein -
LV451_RS12725 2694908..2695279 - 372 WP_003417739.1 FAD-binding protein -
LV451_RS12730 2695177..2695395 - 219 WP_157132559.1 hypothetical protein -
LV451_RS12735 2695422..2695682 - 261 WP_003417741.1 hypothetical protein -
LV451_RS12740 2695797..2696186 + 390 WP_003417745.1 DUF732 domain-containing protein -
LV451_RS12745 2696200..2696493 - 294 WP_003417749.1 DUF3017 domain-containing protein -
LV451_RS12750 2696490..2697335 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
LV451_RS12755 2697459..2697734 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
LV451_RS12760 2697731..2697988 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
LV451_RS12765 2698030..2699220 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
LV451_RS12770 2699337..2699705 + 369 WP_003417765.1 FHA domain-containing protein -
LV451_RS12775 2699702..2700253 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
LV451_RS12780 2700260..2700841 - 582 WP_003417769.1 ATP/GTP-binding protein -
LV451_RS12785 2700822..2701190 - 369 WP_003417772.1 DUF742 domain-containing protein -
LV451_RS12790 2701168..2701560 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T229686 WP_003417760.1 NZ_CP089927:2697731-2697988 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T229686 NZ_CP124508:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT229686 WP_003417757.1 NZ_CP089927:2697459-2697734 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT229686 NZ_CP124508:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References