Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2633147..2633821 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag LV451_RS12560 Protein ID WP_003417282.1
Coordinates 2633147..2633575 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag LV451_RS12565 Protein ID WP_003417286.1
Coordinates 2633579..2633821 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS12535 2628969..2629370 - 402 WP_003417264.1 cytidine deaminase -
LV451_RS12540 2629607..2629945 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
LV451_RS12545 2629942..2630376 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
LV451_RS12550 2630505..2632277 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
LV451_RS12555 2632277..2633068 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
LV451_RS12560 2633147..2633575 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
LV451_RS12565 2633579..2633821 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
LV451_RS12570 2633943..2634557 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
LV451_RS12575 2634554..2635219 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
LV451_RS12580 2635220..2635753 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
LV451_RS12585 2635750..2635884 - 135 Protein_2485 4a-hydroxytetrahydrobiopterin dehydratase -
LV451_RS12590 2635938..2637199 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T229685 WP_003417282.1 NZ_CP089927:c2633575-2633147 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T229685 NZ_CP124507:c141178-140873 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT229685 WP_003417286.1 NZ_CP089927:c2633821-2633579 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT229685 NZ_CP124507:c141398-141180 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References