Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1855867..1856581 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LV451_RS08745 Protein ID WP_003413460.1
Coordinates 1856141..1856581 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LV451_RS08740 Protein ID WP_003413456.1
Coordinates 1855867..1856154 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS08705 1851289..1851534 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LV451_RS08710 1851531..1851935 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LV451_RS08715 1852152..1852772 + 621 WP_003413441.1 DUF4178 domain-containing protein -
LV451_RS08720 1852783..1853277 + 495 WP_003413444.1 DUF2617 family protein -
LV451_RS08725 1853274..1853705 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LV451_RS08730 1853760..1854188 + 429 WP_178121172.1 DUF350 domain-containing protein -
LV451_RS08735 1854185..1855756 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
LV451_RS08740 1855867..1856154 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LV451_RS08745 1856141..1856581 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LV451_RS08750 1856602..1857357 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LV451_RS08755 1857490..1858086 - 597 WP_031696860.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LV451_RS08760 1858094..1858939 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LV451_RS08765 1858968..1859867 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LV451_RS08770 1859995..1860669 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T229675 WP_003413460.1 NZ_CP089927:1856141-1856581 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T229675 NZ_CP124506:2756514-2756621 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT229675 WP_003413456.1 NZ_CP089927:1855867-1856154 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT229675 NZ_CP124506:c2756457-2756402 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References