Detailed information of TA system TA022967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 4893575..4894242
• Replicon: chromosome
• Accession: NC_011004
• Organism: Rhodopseudomonas palustris TIE-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B3QJT1
• Locus tag: RPAL_RS22450
• Protein ID: WP_012497352.1
• Coordinates: 4893832..4894242 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B3QJT0
• Locus tag: RPAL_RS22445
• Protein ID: WP_012497351.1
• Coordinates: 4893575..4893832 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPAL_RS22430	4889767..4890192	-	426	WP_210160543.1	hotdog fold thioesterase	-
RPAL_RS22435	4890340..4891026	+	687	WP_012497350.1	YafY family transcriptional regulator	-
RPAL_RS22440	4891215..4892814	-	1600	Protein_4510	ABC-F family ATP-binding cassette domain-containing protein	-
RPAL_RS22445	4893575..4893832	+	258	WP_012497351.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RPAL_RS22450	4893832..4894242	+	411	WP_012497352.1	type II toxin-antitoxin system VapC family toxin	Toxin
RPAL_RS22455	4894362..4895021	+	660	WP_012497353.1	hypothetical protein	-
RPAL_RS22460	4895398..4896807	-	1410	WP_012497354.1	adenosylhomocysteinase	-
RPAL_RS22465	4897068..4898264	-	1197	WP_011159551.1	methionine adenosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-53)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14968.23 Da
• Isoelectric Point: 10.1786

>T22967 WP_012497352.1 NC_011004:4893832-4894242 [Rhodopseudomonas palustris TIE-1]
MFLIDTVTLSALRKRQRNPNVVAWFERQRTADLFLSAISIGEIERGIARQRATDPEFARALAAWLDRVLTVYGERIVPFD
LRAARRWGALSAALGNDSADLMIAATALEHGLTVVTRNVSDFALTGVALIDPFGKA

Nucleotide

• Length: 411 bp

>T22967 NC_011004:4893832-4894242 [Rhodopseudomonas palustris TIE-1]
ATGTTTCTGATCGACACCGTCACGCTGTCGGCCTTGCGCAAGCGACAGCGGAATCCGAATGTCGTCGCTTGGTTCGAACG
GCAGCGGACGGCCGACCTCTTCCTCAGCGCCATCAGCATCGGCGAGATCGAGCGCGGCATTGCGCGGCAACGCGCGACCG
ATCCGGAGTTTGCGCGCGCACTCGCCGCCTGGCTCGACCGGGTCCTGACCGTCTATGGTGAGCGCATCGTCCCATTCGAT
CTCCGAGCGGCACGTCGCTGGGGCGCCCTCAGCGCAGCGCTCGGCAACGACAGCGCCGACCTGATGATCGCCGCCACCGC
GCTGGAGCACGGACTGACCGTGGTGACGCGGAACGTGTCAGATTTCGCACTGACCGGCGTGGCGTTGATTGATCCGTTCG
GAAAGGCGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9627.86 Da
• Isoelectric Point: 5.8432

>AT22967 WP_012497351.1 NC_011004:4893575-4893832 [Rhodopseudomonas palustris TIE-1]
MAERSWSVQDAKNRFSEVVEAARRSPQTVTKHGKPAVVVVDVAEYQRLQQLERATAPSFADVLLAMPRDDGDFSRDPVRM
RDVEL

Nucleotide

• Length: 258 bp

>AT22967 NC_011004:4893575-4893832 [Rhodopseudomonas palustris TIE-1]
ATGGCCGAGCGCAGTTGGTCGGTGCAGGACGCCAAGAACCGGTTCAGCGAGGTCGTCGAGGCCGCGCGGCGCAGCCCGCA
GACGGTGACCAAGCACGGCAAGCCGGCCGTCGTCGTGGTCGACGTCGCCGAGTACCAACGACTCCAGCAACTCGAGCGCG
CCACCGCCCCGTCATTCGCCGATGTGCTGTTGGCAATGCCGCGGGACGACGGCGACTTTTCGCGTGATCCCGTGCGGATG
CGCGACGTCGAGCTCTGA

Structures

Toxin

• AlphaFold DB: B3QJT1

Antitoxin

• AlphaFold DB: B3QJT0