Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 1323441..1323970 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LV451_RS06220 Protein ID WP_003411124.1
Coordinates 1323441..1323758 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LV451_RS06225 Protein ID WP_003411127.1
Coordinates 1323755..1323970 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS06190 1318578..1319654 + 1077 WP_003411110.1 hypothetical protein -
LV451_RS06195 1319651..1319932 + 282 WP_003411112.1 DUF5703 family protein -
LV451_RS06200 1319968..1321041 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
LV451_RS06205 1321046..1321576 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LV451_RS06210 1321624..1322970 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LV451_RS06220 1323441..1323758 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LV451_RS06225 1323755..1323970 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LV451_RS06230 1324225..1325283 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LV451_RS06235 1325413..1325769 - 357 WP_003411130.1 hypothetical protein -
LV451_RS06240 1325864..1326646 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LV451_RS06245 1326914..1327204 - 291 WP_003900476.1 YggT family protein -
LV451_RS06250 1327366..1328022 - 657 WP_003411133.1 cell division protein SepF -
LV451_RS06255 1328088..1328864 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T229669 WP_003411124.1 NZ_CP089927:c1323758-1323441 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T229669 NZ_CP124506:976016-976423 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT229669 WP_003411127.1 NZ_CP089927:c1323970-1323755 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT229669 NZ_CP124506:975769-976035 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References