Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 1154412..1155310 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag LV451_RS05405 Protein ID WP_003410001.1
Coordinates 1154412..1154972 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag LV451_RS05410 Protein ID WP_003410003.1
Coordinates 1154969..1155310 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS05375 1149581..1150234 - 654 WP_003409976.1 cutinase Cfp21 -
LV451_RS05380 1150349..1150579 + 231 WP_003409980.1 DUF167 domain-containing protein -
LV451_RS05385 1150664..1151575 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LV451_RS05390 1151684..1152283 + 600 WP_003409989.1 L-lysine exporter -
LV451_RS05395 1152699..1153127 + 429 WP_003409992.1 cellulose-binding protein -
LV451_RS05400 1153353..1153892 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
LV451_RS05405 1154412..1154972 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
LV451_RS05410 1154969..1155310 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
LV451_RS05415 1155396..1155653 + 258 WP_003410006.1 hypothetical protein -
LV451_RS05420 1155554..1155889 - 336 WP_003410009.1 dehydrogenase -
LV451_RS05425 1155978..1156322 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
LV451_RS05430 1156316..1156564 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
LV451_RS05435 1156664..1158979 - 2316 WP_003899120.1 cation transporter ATPase CptG -
LV451_RS05440 1158976..1159248 - 273 WP_003410017.1 DUF1490 family protein -
LV451_RS05445 1159301..1159657 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T229663 WP_003410001.1 NZ_CP089927:c1154972-1154412 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T229663 NZ_CP124506:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT229663 WP_003410003.1 NZ_CP089927:c1155310-1154969 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT229663 NZ_CP124506:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References