Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1147086..1147774 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag LV451_RS05360 Protein ID WP_003409958.1
Coordinates 1147086..1147505 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag LV451_RS05365 Protein ID WP_003409968.1
Coordinates 1147514..1147774 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS05340 1142581..1143429 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
LV451_RS05345 1143392..1144837 - 1446 WP_003899115.1 APC family permease -
LV451_RS05350 1145016..1145702 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
LV451_RS05355 1145893..1146861 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
LV451_RS05360 1147086..1147505 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
LV451_RS05365 1147514..1147774 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LV451_RS05370 1147917..1149593 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
LV451_RS05375 1149581..1150234 - 654 WP_003409976.1 cutinase Cfp21 -
LV451_RS05380 1150349..1150579 + 231 WP_003409980.1 DUF167 domain-containing protein -
LV451_RS05385 1150664..1151575 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LV451_RS05390 1151684..1152283 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T229662 WP_003409958.1 NZ_CP089927:c1147505-1147086 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T229662 NZ_CP124503:c142410-142105 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT229662 WP_003409968.1 NZ_CP089927:c1147774-1147514 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT229662 NZ_CP124503:c142630-142412 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References