Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1125353..1125897 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag LV451_RS05240 Protein ID WP_003409896.1
Coordinates 1125353..1125649 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag LV451_RS05245 Protein ID WP_003409899.1
Coordinates 1125646..1125897 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS05185 1120386..1120736 - 351 WP_003899096.1 hypothetical protein -
LV451_RS05190 1120747..1121649 - 903 WP_003899097.1 hypothetical protein -
LV451_RS05195 1121670..1121861 - 192 WP_003409876.1 hypothetical protein -
LV451_RS05200 1121862..1122158 - 297 WP_003409877.1 hypothetical protein -
LV451_RS05205 1122398..1122613 + 216 WP_003409878.1 antitoxin -
LV451_RS05210 1122610..1122921 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
LV451_RS05215 1122895..1123416 - 522 WP_003904745.1 hypothetical protein -
LV451_RS05220 1123391..1123768 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
LV451_RS05225 1123810..1124259 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
LV451_RS05230 1124256..1124801 + 546 WP_003409891.1 SecB-like chaperone -
LV451_RS05235 1124690..1125304 - 615 WP_003901296.1 hypothetical protein -
LV451_RS05240 1125353..1125649 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LV451_RS05245 1125646..1125897 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LV451_RS05250 1125884..1126378 + 495 WP_003899099.1 hypothetical protein -
LV451_RS05255 1126538..1126945 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
LV451_RS05260 1126949..1127221 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LV451_RS05265 1127254..1128474 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
LV451_RS05270 1129373..1130170 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T229661 WP_003409896.1 NZ_CP089927:c1125649-1125353 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T229661 NZ_CP124502:c4889524-4889417 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT229661 WP_003409899.1 NZ_CP089927:c1125897-1125646 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT229661 NZ_CP124502:4889573-4889638 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References