Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 164843..165411 Replicon chromosome
Accession NZ_CP089927
Organism Mycobacterium tuberculosis strain M20

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag LV451_RS00855 Protein ID WP_003405865.1
Coordinates 165037..165411 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag LV451_RS00850 Protein ID WP_003405863.1
Coordinates 164843..165040 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV451_RS00830 160884..161522 - 639 WP_003898730.1 lipid droplet-associated protein -
LV451_RS00835 161612..162619 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
LV451_RS00840 162636..163619 - 984 WP_003898731.1 hypothetical protein -
LV451_RS00845 163682..164755 + 1074 WP_003898732.1 redox-regulated ATPase YchF -
LV451_RS00850 164843..165040 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LV451_RS00855 165037..165411 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
LV451_RS00860 165614..166312 + 699 WP_003898733.1 hypothetical protein -
LV451_RS00865 166430..166615 + 186 WP_003901093.1 hypothetical protein -
LV451_RS00870 166542..166817 - 276 WP_003405867.1 hypothetical protein -
LV451_RS00875 167060..167383 + 324 WP_003405871.1 putative quinol monooxygenase -
LV451_RS00880 167398..168096 - 699 WP_031646953.1 hypothetical protein -
LV451_RS00885 168130..168339 + 210 WP_003911400.1 hypothetical protein -
LV451_RS00890 168291..169061 - 771 Protein_174 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T229650 WP_003405865.1 NZ_CP089927:165037-165411 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

>T229650 NZ_CP124502:c2287955-2287848 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT229650 WP_003405863.1 NZ_CP089927:164843-165040 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp

>AT229650 NZ_CP124502:2288003-2288069 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References