Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4678050..4678566 Replicon chromosome
Accession NZ_CP089926
Organism Klebsiella pneumoniae strain KP111

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LVQ71_RS22990 Protein ID WP_002886902.1
Coordinates 4678050..4678334 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LVQ71_RS22995 Protein ID WP_002886901.1
Coordinates 4678324..4678566 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ71_RS22965 (4673446) 4673446..4673709 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LVQ71_RS22970 (4673839) 4673839..4674012 + 174 WP_040248667.1 hypothetical protein -
LVQ71_RS22975 (4674015) 4674015..4674758 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LVQ71_RS22980 (4675115) 4675115..4677253 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
LVQ71_RS22985 (4677582) 4677582..4678046 + 465 WP_251335751.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LVQ71_RS22990 (4678050) 4678050..4678334 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVQ71_RS22995 (4678324) 4678324..4678566 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LVQ71_RS23000 (4678644) 4678644..4680554 - 1911 WP_009486549.1 PRD domain-containing protein -
LVQ71_RS23005 (4680577) 4680577..4681731 - 1155 WP_009309312.1 lactonase family protein -
LVQ71_RS23010 (4681798) 4681798..4682538 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T229645 WP_002886902.1 NZ_CP089926:c4678334-4678050 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T229645 NZ_CP124502:1043923-1044237 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT229645 WP_002886901.1 NZ_CP089926:c4678566-4678324 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT229645 NZ_CP124502:1043687-1043920 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References