Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3969157..3969776 Replicon chromosome
Accession NZ_CP089926
Organism Klebsiella pneumoniae strain KP111

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LVQ71_RS19660 Protein ID WP_002892050.1
Coordinates 3969558..3969776 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LVQ71_RS19655 Protein ID WP_002892066.1
Coordinates 3969157..3969531 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ71_RS19645 (3964309) 3964309..3965502 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LVQ71_RS19650 (3965525) 3965525..3968671 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LVQ71_RS19655 (3969157) 3969157..3969531 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LVQ71_RS19660 (3969558) 3969558..3969776 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LVQ71_RS19665 (3969935) 3969935..3970501 + 567 WP_002892030.1 maltose O-acetyltransferase -
LVQ71_RS19670 (3970473) 3970473..3970613 - 141 WP_004147370.1 hypothetical protein -
LVQ71_RS19675 (3970634) 3970634..3971104 + 471 WP_002892026.1 YlaC family protein -
LVQ71_RS19680 (3971079) 3971079..3972530 - 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
LVQ71_RS19685 (3972631) 3972631..3973329 + 699 WP_002892021.1 GNAT family protein -
LVQ71_RS19690 (3973326) 3973326..3973466 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LVQ71_RS19695 (3973466) 3973466..3973729 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T229643 WP_002892050.1 NZ_CP089926:3969558-3969776 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T229643 NZ_CP124502:863296-863673 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT229643 WP_002892066.1 NZ_CP089926:3969157-3969531 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT229643 NZ_CP124502:862839-863207 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References