Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801328..801985 Replicon chromosome
Accession NZ_CP089926
Organism Klebsiella pneumoniae strain KP111

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVQ71_RS03985 Protein ID WP_002916310.1
Coordinates 801575..801985 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVQ71_RS03980 Protein ID WP_002916312.1
Coordinates 801328..801594 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ71_RS03955 (796536) 796536..797969 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LVQ71_RS03960 (798088) 798088..798816 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVQ71_RS03965 (798866) 798866..799177 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LVQ71_RS03970 (799341) 799341..800000 + 660 WP_002916317.1 hemolysin III family protein -
LVQ71_RS03975 (800099) 800099..801082 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LVQ71_RS03980 (801328) 801328..801594 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVQ71_RS03985 (801575) 801575..801985 + 411 WP_002916310.1 protein YgfX Toxin
LVQ71_RS03990 (801992) 801992..802513 - 522 WP_004144730.1 flavodoxin FldB -
LVQ71_RS03995 (802614) 802614..803510 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LVQ71_RS04000 (803533) 803533..804246 + 714 WP_071081169.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVQ71_RS04005 (804252) 804252..805985 + 1734 WP_071081170.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229633 WP_002916310.1 NZ_CP089926:801575-801985 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229633 NZ_CP124500:c3546277-3545975 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229633 WP_002916312.1 NZ_CP089926:801328-801594 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229633 NZ_CP124500:c3545939-3545598 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References