Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 383385..385011 Replicon plasmid unnamed1
Accession NZ_CP089920
Organism Rahnella victoriana strain JZ-GX1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag J9880_RS23115 Protein ID WP_232770512.1
Coordinates 383385..384710 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag J9880_RS23120 Protein ID WP_119827398.1
Coordinates 384715..385011 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9880_RS23105 (J9880_23105) 379569..380456 + 888 WP_232770511.1 LysR family transcriptional regulator -
J9880_RS23110 (J9880_23110) 380837..383314 + 2478 WP_131694352.1 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family -
J9880_RS23115 (J9880_23115) 383385..384710 - 1326 WP_232770512.1 type II toxin-antitoxin system HipA family toxin Toxin
J9880_RS23120 (J9880_23120) 384715..385011 - 297 WP_119827398.1 helix-turn-helix transcriptional regulator Antitoxin
J9880_RS23125 (J9880_23125) 385208..386167 - 960 WP_195817874.1 methyltransferase -
J9880_RS23130 (J9880_23130) 386648..387358 + 711 WP_232770513.1 GntR family transcriptional regulator -
J9880_RS23135 (J9880_23135) 387355..388554 - 1200 WP_119825746.1 enolase C-terminal domain-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid oqxB / blaRAHN-2 vipA/tssB / vipB/tssC / vasE/tssK / hcp/tssD / clpV/tssH / vgrG/tssI / tli1 / KPHS_23120 / tssF / hcp1 / AHA_1832 / AHA_1833 / clpB 1..722843 722843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-70)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49831.02 Da        Isoelectric Point: 6.8968

>T229627 WP_232770512.1 NZ_CP089920:c384710-383385 [Rahnella victoriana]
MRRAQQRLAIWMNGIPVGYWDKQKGEDRLQYLPSWREDQQGRPLSLSLPFTPGNQVHRGNVVRDYFDNLLPDSEGIRRRL
AARYHAESLEPFDLLTELGRDCVGAIQLLNVGDQPAGIFTIRQRLLSEPEIAGMLRNTAGMLPGQNNQDEDLRLSIAGAQ
EKTALLWHNGQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWICSLIIEQFGLAVAKAQVAQFEDQKALIVERFD
RKLSSDGGWWIRLPQEDMCQAMGVSPLRKYQSDGGPGITDIMEILSRSEQAQQDQSQFFKAQIIFWLMAATDGHAKNFSL
AHLPQNRYCMTPLYDILSAWPVIGHGNNKIAWQKCKLAMAVRGSSNYYLISKIQRRHWIKQGEQSGLGKRQIETMIDEII
ALVPVVIENVARQLPASFPPELADAIFTGMEQQRVRLQAQA

Download         Length: 1326 bp

>T229627 NZ_CP124500:1923304-1923555 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11264.97 Da        Isoelectric Point: 9.8509

>AT229627 WP_119827398.1 NZ_CP089920:c385011-384715 [Rahnella victoriana]
MKTVYPLKTLNQLRPFLVGFRKEKGLTQKDVSEKLGVTQQTYARLEANPAAASLDRLFRVFNVLGIEMVFSSQSDPEKPS
MEEIKQDYLSTPARKEQW

Download         Length: 297 bp

>AT229627 NZ_CP124500:1923552-1923806 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References