Detailed information of TA system TA229622

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2472540..2473239
• Replicon: chromosome
• Accession: NZ_CP089919
• Organism: Rahnella victoriana strain JZ-GX1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: J9880_RS11470
• Protein ID: WP_232769347.1
• Coordinates: 2472787..2473239 (+)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: J9880_RS11465
• Protein ID: WP_095925209.1
• Coordinates: 2472540..2472806 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9880_RS11435 (J9880_11435)	2467755..2468060	-	306	WP_095923377.1	YqjD family protein	-
J9880_RS11440 (J9880_11440)	2468333..2469529	+	1197	WP_119822903.1	MFS transporter	-
J9880_RS11445 (J9880_11445)	2469656..2469991	+	336	WP_095923373.1	DUF2002 family protein	-
J9880_RS11450 (J9880_11450)	2470048..2470488	-	441	WP_095923371.1	DUF1198 domain-containing protein	-
J9880_RS11455 (J9880_11455)	2470688..2471218	+	531	WP_095923368.1	class IV adenylate cyclase	-
J9880_RS11460 (J9880_11460)	2471267..2472259	-	993	WP_095923366.1	tRNA-modifying protein YgfZ	-
J9880_RS11465 (J9880_11465)	2472540..2472806	+	267	WP_095925209.1	FAD assembly factor SdhE	Antitoxin
J9880_RS11470 (J9880_11470)	2472787..2473239	+	453	WP_232769347.1	protein YgfX	Toxin
J9880_RS11475 (J9880_11475)	2473276..2473794	-	519	WP_095923361.1	flavodoxin FldB	-
J9880_RS11480 (J9880_11480)	2473894..2474853	+	960	WP_095923359.1	site-specific tyrosine recombinase XerD	-
J9880_RS11485 (J9880_11485)	2474879..2475598	+	720	WP_095923357.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
J9880_RS11490 (J9880_11490)	2475605..2477338	+	1734	WP_095923355.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-139)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 17568.83 Da
• Isoelectric Point: 11.8224

>T229622 WP_232769347.1 NZ_CP089919:2472787-2473239 [Rahnella victoriana]
VALWRCDLRVSWRSQLISLGSYGAVMLLILLAPWPAGYWPVWMTLLLLVLFECIRSQRRITARTGEIILLEDHRLLWRGH
EWQIKQPVWMISSGVLLSLRREKRKGGLAQAMRSSRQRLWLASDSMSLEEWRRLRQILLSNLPDSPVRPG

Nucleotide

• Length: 453 bp

>T229622 NZ_CP124500:359085-359612 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10450.94 Da
• Isoelectric Point: 5.1236

>AT229622 WP_095925209.1 NZ_CP089919:2472540-2472806 [Rahnella victoriana]
MDINNRSRVHWACRRGMRELDISIMPFFEYEYDSLSETDKEVFVRLLTCDDPDLFNWLMNHGEPKDSELQRMVALIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT229622 NZ_CP124500:358812-359078 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA