Detailed information of TA system TA022961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2389632..2390302
• Replicon: chromosome
• Accession: NC_011004
• Organism: Rhodopseudomonas palustris TIE-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q6N8B2
• Locus tag: RPAL_RS10950
• Protein ID: WP_011157547.1
• Coordinates: 2389632..2390042 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RPAL_RS26805
• Protein ID: WP_011157548.1
• Coordinates: 2390039..2390302 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPAL_RS27340	2386009..2386335	+	327	WP_150104521.1	hypothetical protein	-
RPAL_RS10940	2386502..2388292	+	1791	WP_012495518.1	sulfatase-like hydrolase/transferase	-
RPAL_RS10945	2388304..2389377	+	1074	WP_150104522.1	transporter	-
RPAL_RS10950	2389632..2390042	-	411	WP_011157547.1	type II toxin-antitoxin system VapC family toxin	Toxin
RPAL_RS26805	2390039..2390302	-	264	WP_011157548.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
RPAL_RS10955	2390483..2390908	+	426	WP_012495520.1	cupin domain-containing protein	-
RPAL_RS10960	2391005..2392174	-	1170	WP_012495521.1	DUF2865 domain-containing protein	-
RPAL_RS10965	2392360..2392668	-	309	WP_011157551.1	hypothetical protein	-
RPAL_RS10970	2393070..2394545	+	1476	WP_012495522.1	cysteine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (9-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15136.48 Da
• Isoelectric Point: 5.6802

>T22961 WP_011157547.1 NC_011004:c2390042-2389632 [Rhodopseudomonas palustris TIE-1]
MSGWMLDTNVASHVIRGDRREIIERLVALPISDVVISSITEGELLYGLAKRGYPTALSERVREFLLRVDVLPWDHEVTKT
YADLRAVCEAKGVTLSPLDMMIAAHAAATNATLVTRDKAFSRVPSPLRIEDWAEMS

Nucleotide

• Length: 411 bp

>T22961 NC_011004:c2390042-2389632 [Rhodopseudomonas palustris TIE-1]
ATGAGTGGCTGGATGCTCGATACCAACGTCGCCAGCCATGTCATCAGGGGCGACCGGCGCGAGATCATCGAGCGGCTAGT
CGCTTTGCCGATCTCGGACGTCGTCATCTCATCGATCACAGAAGGTGAACTCCTCTACGGCCTGGCTAAGCGCGGCTATC
CCACCGCGTTATCCGAACGCGTCCGAGAATTTCTACTCCGCGTCGACGTCCTACCGTGGGATCACGAGGTGACGAAGACT
TACGCCGACCTGCGCGCAGTCTGCGAAGCCAAAGGCGTCACACTCTCTCCTCTCGACATGATGATCGCTGCCCATGCCGC
TGCGACAAACGCAACGTTGGTCACGCGCGACAAGGCCTTCAGCCGCGTGCCTTCACCATTGCGGATCGAGGACTGGGCAG
AGATGAGTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9888.91 Da
• Isoelectric Point: 4.7969

>AT22961 WP_011157548.1 NC_011004:c2390302-2390039 [Rhodopseudomonas palustris TIE-1]
VTSRTAKIFTTGRSQAVRLPAEFRFEGSEVFVRRDPRTGDVILSRKPDSWDGLLQLHQSADVPDDFLGPSDRSQLPQDRD
PFEGWTE

Nucleotide

• Length: 264 bp

>AT22961 NC_011004:c2390302-2390039 [Rhodopseudomonas palustris TIE-1]
GTGACGTCTCGAACCGCCAAGATTTTCACAACTGGACGCAGCCAAGCTGTCCGACTGCCAGCGGAGTTTCGCTTCGAGGG
CAGCGAGGTGTTTGTACGCCGTGATCCGCGGACCGGCGATGTCATTCTGTCCCGAAAACCGGACTCCTGGGACGGCCTAC
TCCAGCTTCACCAGTCGGCGGATGTACCCGACGACTTCTTGGGACCGTCCGACCGTAGCCAGCTTCCGCAGGATCGCGAT
CCGTTCGAAGGCTGGACCGAATGA

Structures

Toxin

• AlphaFold DB: Q6N8B2