Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4938409..4940090 Replicon chromosome
Accession NZ_CP089884
Organism Klebsiella pneumoniae strain KP102

Toxin (Protein)


Gene name mosT Uniprot ID A0A483J778
Locus tag LR951_RS24180 Protein ID WP_023159070.1
Coordinates 4938409..4939326 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag LR951_RS24185 Protein ID WP_004177809.1
Coordinates 4939332..4940090 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LR951_RS24160 (LR951_24115) 4933715..4935235 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
LR951_RS24165 (LR951_24120) 4935232..4936230 + 999 WP_002885172.1 ribose ABC transporter permease -
LR951_RS24170 (LR951_24125) 4936261..4937202 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LR951_RS24175 (LR951_24130) 4937277..4938284 + 1008 WP_004177805.1 carbohydrate kinase family protein -
LR951_RS24180 (LR951_24135) 4938409..4939326 - 918 WP_023159070.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LR951_RS24185 (LR951_24140) 4939332..4940090 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LR951_RS24190 (LR951_24145) 4940176..4940904 - 729 WP_023159071.1 response regulator transcription factor -
LR951_RS24195 (LR951_24150) 4941177..4943324 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
LR951_RS24200 (LR951_24155) 4943554..4944240 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34786.29 Da        Isoelectric Point: 5.7845

>T229608 WP_023159070.1 NZ_CP089884:c4939326-4938409 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARRTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T229608 NZ_CP124498:2233856-2233958 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT229608 WP_004177809.1 NZ_CP089884:c4940090-4939332 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT229608 NZ_CP124498:c2233996-2233728 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483J778

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References